Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade - Wikidata - awgldk - TriplyDB

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

http://www.wikidata.org/entity/Q28472122

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A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications Resolution of praziquantel Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols Identification of oxadiazoles as new drug leads for the control of schistosomiasis Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects Compound Management for Quantitative High-Throughput Screening Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites The redox biology of schistosome parasites and applications for drug development Sexual Preferences in Nutrient Utilization Regulate Oxygen Consumption and Reactive Oxygen Species Generation in Schistosoma mansoni: Potential Implications for Parasite Redox Biology 3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compounds High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction A robotic platform for quantitative high-throughput screening The pilot phase of the NIH Chemical Genomics Center.A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A High-throughput screening and biosensing with fluorescent C. elegans strains.Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis.Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.Identification of small molecule modulators of gene transcription with anticancer activity.Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases.High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase.Characterization of the methionine sulfoxide reductases of Schistosoma mansoni.Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.Molecular and functional characterization of a putative PA28γ proteasome activator orthologue in Schistosoma mansoni A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs.Prospects for the control of neglected tropical diseases by mass drug administration.In vitro and in vivo trematode models for chemotherapeutic studies.Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation.Metabolite-biomarker investigations in the life cycle of and infection with Schistosoma.Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery Thioredoxin reductase and its inhibitors.Modern approaches to accelerate discovery of new antischistosomal drugs.The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.Antischistosomal activity of hederacochiside C against Schistosoma japonicum harbored in experimentally infected animals.

P2860

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P2860

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

http://www.wikidata.org/entity/Q28472122

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2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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Quantitative high-throughput s ...... istosoma mansoni redox cascade

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Quantitative high-throughput s ...... istosoma mansoni redox cascade

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Quantitative high-throughput s ...... istosoma mansoni redox cascade

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Quantitative high-throughput s ...... istosoma mansoni redox cascade

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PLOS Neglected Tropical Diseases

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Quantitative high-throughput s ...... istosoma mansoni redox cascade

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Craig J Thomas

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Creative Commons Attribution 2.5 Unported

P2860

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis

Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa

NIH Molecular Libraries Initiative.

LeadScope: software for exploring large sets of screening data.

High-throughput assays for promiscuous inhibitors.

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide.

Chemotherapeutic approaches to schistosomes: current knowledge and outlook.

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