Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes
about
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio choleraeAllosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralogMathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identificationPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesSpermine synthase.Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylaseAdaptive responses to purine starvation in Leishmania donovani.A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei.Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing ProteinsGMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozymeCurrent status of the polyamine research fieldProduct feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozymeNovel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme.Mammalian polyamine metabolism and functionRelief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralogArginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.Trypanocidal drugs: mechanisms, resistance and new targets.Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.State of the art in African trypanosome drug discovery.Evaluating 5-Nitrothiazoles as Trypanocidal Agents.The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.Different polyamine pathways from bacteria have replaced eukaryotic spermidine biosynthesis in ciliates Tetrahymena thermophila and Paramecium tetaurelia.Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.
P2860
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P2860
Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Regulated expression of an ess ...... thesis in African trypanosomes
@ast
Regulated expression of an ess ...... thesis in African trypanosomes
@en
Regulated expression of an ess ...... thesis in African trypanosomes
@nl
type
label
Regulated expression of an ess ...... thesis in African trypanosomes
@ast
Regulated expression of an ess ...... thesis in African trypanosomes
@en
Regulated expression of an ess ...... thesis in African trypanosomes
@nl
prefLabel
Regulated expression of an ess ...... thesis in African trypanosomes
@ast
Regulated expression of an ess ...... thesis in African trypanosomes
@en
Regulated expression of an ess ...... thesis in African trypanosomes
@nl
P2860
P921
P1433
P1476
Regulated expression of an ess ...... thesis in African trypanosomes
@en
P2093
Erin K Willert
Margaret A Phillips
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000183
P407
P577
2008-10-01T00:00:00Z