Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer - Wikidata - awgldk - TriplyDB

Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

http://www.wikidata.org/entity/Q28475229

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ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7 FoxO3a and disease progression.MicroRNA-96 inhibits FoxO3a function in IPF fibroblasts on type I collagen matrix.Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer Foxo3a expression is a prognostic marker in breast cancer.BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers.Increased expression of forkhead box M1 is associated with aggressive phenotype and poor prognosis in estrogen receptor-positive breast cancer.Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer Acidic Fibroblast Growth Factor Promotes Endothelial Progenitor Cells Function via Akt/FOXO3a Pathway.The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas.Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.Mechanisms of doxorubicin resistance in hepatocellular carcinoma Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a.Survival factor NFIL3 restricts FOXO-induced gene expression in cancer BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.A role for FOXO1 in BCR-ABL1-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells.Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma.Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance.Antagonism between FOXO and MYC Regulates Cellular Powerhouse.Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance.Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer.Resistance to the mTOR-inhibitor RAD001 elevates integrin α2- and β1-triggered motility, migration and invasion of prostate cancer cells β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.FOXO transcription factors at the interface of metabolism and cancer.Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin.FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function.Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer Nuclear Localization Marker of FOXO3a: Can it be Used to Predict Doxorubicin Response?Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development.Forkhead box transcription factors in cancer initiation, progression and chemotherapeutic drug response.Spontaneous presence of FOXO3-specific T cells in cancer patients.FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3.Actionable mutations in canine hemangiosarcoma.Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox).

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Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

http://www.wikidata.org/entity/Q28475229

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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type

label

Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Constitutively nuclear FOXO3a ...... osphorylation in breast cancer

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Ana R Gomes

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Andrew Sunters

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Christina T Karadedou

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Jie Chen

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Julie Millour

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Kelvin Y K Chan

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Lai Han Wu

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Lara J Monteiro

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San Yu Wong

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Ting-Ting Ng

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

A new fork for clinical application: targeting forkhead transcription factors in cancer

The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

The emerging roles of forkhead box (Fox) proteins in cancer

Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer

Cellular and molecular pharmacology of antiestrogen action and resistance.

Molecular and pharmacological aspects of antiestrogen resistance.

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