The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target - Wikidata - awgldk - TriplyDB

The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target

The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target

http://www.wikidata.org/entity/Q28475720

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Co-evolution between an endosymbiont and its nematode host: Wolbachia asymmetric posterior localization and AP polarity establishment Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment Characterization of transcription factors that regulate the type IV secretion system and riboflavin biosynthesis in Wolbachia of Brugia malayi Reactive oxygen species production and Brugia pahangi survivorship in Aedes polynesiensis with artificial Wolbachia infection types Wolbachia transcription elongation factor "Wol GreA" interacts with α2ββ'σ subunits of RNA polymerase through its dimeric C-terminal domain Iron necessity: the secret of Wolbachia's success?Wolbachia: Can we save lives with a great pandemic?Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes.Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans The Wolbachia endosymbiont as an anti-filarial nematode target Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes.Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.Heme and blood-feeding parasites: friends or foes?Make it, take it, or leave it: heme metabolism of parasites.Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode.Ocular onchocerciasis: current management and future prospects A potential role for the interaction of Wolbachia surface proteins with the Brugia malayi glycolytic enzymes and cytoskeleton in maintenance of endosymbiosis Gene expression in gut symbiotic organ of stinkbug affected by extracellular bacterial symbiont.Concurrent transcriptional profiling of Dirofilaria immitis and its Wolbachia endosymbiont throughout the nematode life cycle reveals coordinated gene expression An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegans.Homology modeling of NAD+-dependent DNA ligase of the Wolbachia endosymbiont of Brugia malayi and its drug target potential using dispiro-cycloalkanones.Draft genome of Brugia pahangi: high similarity between B. pahangi and B. malayi Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo.Glucose and Glycogen Metabolism in Brugia malayi Is Associated with Wolbachia Symbiont Fitness.Autophagy regulates Wolbachia populations across diverse symbiotic associations.Filarial and Wolbachia genomics Defining Brugia malayi and Wolbachia symbiosis by stage-specific dual RNA-seq.Nematode-bacterium symbioses--cooperation and conflict revealed in the "omics" age.Mosaic composition of ribA and wspB genes flanking the virB8-D4 operon in the Wolbachia supergroup B-strain, wStr.Acquisition of exogenous haem is essential for tick reproduction Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes.Molecular characterization of an rsmD-like rRNA methyltransferase from the Wolbachia endosymbiont of Brugia malayi and antifilarial activity of specific inhibitors of the enzyme.Heme acquisition in the parasitic filarial nematode Brugia malayi.wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.Towards novel antifilarial drugs: challenges and recent developments.Current drug targets for helminthic diseases.Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience.Absence of the Filarial Endosymbiont Wolbachia in Seal Heartworm (Acanthocheilonema spirocauda) but Evidence of Ancient Lateral Gene Transfer.

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The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target

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2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode

Draft genome of the filarial nematode parasite Brugia malayi

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Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis

Functional genomic analysis of C. elegans molting

Structural and mechanistic basis of porphyrin metallation by ferrochelatase

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Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

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