Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo
about
Finding the end: recruitment of telomerase to telomeresThe N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalizationA mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.InTERTpreting telomerase structure and functionGenetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies.Direct involvement of the TEN domain at the active site of human telomeraseHuman telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.Recognizing familial myeloid leukemia in adults.Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.Inhibition of telomerase activity by dominant-negative hTERT retards the growth of breast cancer cells.Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms.Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.
P2860
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P2860
Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Human telomerase reverse trans ...... function in vitro and in vivo
@ast
Human telomerase reverse trans ...... function in vitro and in vivo
@en
Human telomerase reverse trans ...... function in vitro and in vivo
@nl
type
label
Human telomerase reverse trans ...... function in vitro and in vivo
@ast
Human telomerase reverse trans ...... function in vitro and in vivo
@en
Human telomerase reverse trans ...... function in vitro and in vivo
@nl
prefLabel
Human telomerase reverse trans ...... function in vitro and in vivo
@ast
Human telomerase reverse trans ...... function in vitro and in vivo
@en
Human telomerase reverse trans ...... function in vitro and in vivo
@nl
P2093
P2860
P1433
P1476
Human telomerase reverse trans ...... function in vitro and in vivo
@en
P2093
Allison R Tsang
Deirdre A Lobb
Haley D M Wyatt
Tara L Beattie
P2860
P356
10.1371/JOURNAL.PONE.0007176
P407
P577
2009-09-24T00:00:00Z