Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells - Wikidata - awgldk - TriplyDB

Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells

Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells

http://www.wikidata.org/entity/Q28476841

about

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility.Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.Gestational hypoxia and epigenetic programming of brain development disorders.Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.Identification of hypermethylation in hepatocyte cell adhesion molecule gene promoter region in bladder carcinoma.Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein Chromatin as an oxygen sensor and active player in the hypoxia response.Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective.Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics.New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes.Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets

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Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells

http://www.wikidata.org/entity/Q28476841

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

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2011年論文

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2011年论文

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name

Aberrant promoter CpG methylat ...... diverse set of malignant cells

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Aberrant promoter CpG methylat ...... diverse set of malignant cells

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Aberrant promoter CpG methylat ...... diverse set of malignant cells

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type

label

Aberrant promoter CpG methylat ...... diverse set of malignant cells

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Aberrant promoter CpG methylat ...... diverse set of malignant cells

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Aberrant promoter CpG methylat ...... diverse set of malignant cells

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prefLabel

Aberrant promoter CpG methylat ...... diverse set of malignant cells

@ast

Aberrant promoter CpG methylat ...... diverse set of malignant cells

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Aberrant promoter CpG methylat ...... diverse set of malignant cells

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JOURNAL.PONE.0014617

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Aberrant promoter CpG methylat ...... diverse set of malignant cells

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Adam J Case

http://www.w3.org/2001/XMLSchema#string

Frederick E Domann

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Matthew P Fitzgerald

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Melissa L T Teoh

http://www.w3.org/2001/XMLSchema#string

Sabine U Vorrink

http://www.w3.org/2001/XMLSchema#string

Sujatha Venkataraman

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Trenton L Place

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

Targeting HIF-1 for cancer therapy

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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scholarly article

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10.1371/JOURNAL.PONE.0014617

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1

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