Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
about
Engineered IgG1-Fc--one fragment to bind them allStability engineering of the human antibody repertoireMechanism of Protein Kinetic Stabilization by Engineered Disulfide CrosslinksEngineered Fc based antibody domains and fragments as novel scaffolds.Disulfide linkage engineering for improving biophysical properties of human VH domains.Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display.Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations.Engineered soluble monomeric IgG1 CH3 domain: generation, mechanisms of function, and implications for design of biological therapeutics.Acid-induced aggregation propensity of nivolumab is dependent on the Fc.Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding.Molecular engineering of antibodies for therapeutic and diagnostic purposes.Significant impact of single N-glycan residues on the biological activity of Fc-based antibody-like fragments.Binding structures and energies of the human neonatal Fc receptor with human Fc and its mutants by molecular modeling and dynamics simulations.The making of bispecific antibodiesEngineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics.Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen.An antibody with Fab-constant domains exchanged for a pair of CH3 domains.Stabilization of the third fibronectin type III domain of human tenascin-C through minimal mutation and rational design.Stabilization of the CD81 Large Extracellular Loop with Disulfide Bonds Improves Its Amenability for Peptide Grafting
P2860
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P2860
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@ast
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@en
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@nl
type
label
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@ast
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@en
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@nl
prefLabel
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@ast
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@en
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@nl
P2860
P3181
P1433
P1476
Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds
@en
P2093
Florian Rüker
Johannes Stadlmann
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0030083
P407
P577
2012-01-17T00:00:00Z