Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma
about
Novel strategies to target the ubiquitin proteasome system in multiple myelomaSmall molecule compounds targeting the p53 pathway: are we finally making progress?Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signallingAnti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signalingmiR-92a inhibits vascular smooth muscle cell apoptosis: role of the MKK4-JNK pathwayRITA displays anti-tumor activity in medulloblastomas independent of TP53 status.p53 abnormalities and potential therapeutic targeting in multiple myeloma.Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma.Targeting p53 by small molecules in hematological malignancies.Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleenRITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of mir-99a ∼ 125b cluster function by seed-targeting inhibitors in multiple myeloma cellsTargeting the p53 pathway.Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cellsc-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.Effects of β-catenin on differentially expressed genes in multiple myeloma.Logic programming reveals alteration of key transcription factors in multiple myeloma.Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approachPharmacological activation of wild-type p53 in the therapy of leukemia.The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade.Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway.RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents.Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation.Differential Molecular Stress Responses to Low Compared to High Doses of Ionizing Radiation in Normal Human Fibroblasts.Targeting p53 by small molecule p53 activators in multiple myeloma.Thyroid hormones improve cardiac function and decrease expression of pro-apoptotic proteins in the heart of rats 14 days after infarction.A linear programming computational framework integrates phosphor-proteomics and prior knowledge to predict drug efficacy.Cell cycle arrest and apoptosis induced by Porphyromonas gingivalis requires JNK- and p53-mediated p38 activation in human trophoblasts.MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1.Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade
P2860
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P2860
Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@ast
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@en
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@nl
type
label
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@ast
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@en
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@nl
prefLabel
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@ast
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@en
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@nl
P2093
P2860
P1433
P1476
Targeting p53 via JNK pathway: ...... signaling in multiple myeloma
@en
P2093
Hong Chang
Manujendra N Saha
Xiaoming Wang
Xiaoyun Zhu
Yijun Yang
P2860
P304
P356
10.1371/JOURNAL.PONE.0030215
P407
P577
2012-01-01T00:00:00Z