The impact of small molecule binding on the energy landscape of the intrinsically disordered protein C-myc
about
Small-molecule inhibitors of the Myc oncoproteinElucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2Analytical methods for structural ensembles and dynamics of intrinsically disordered proteinsLigand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteinsDirect inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.Mechanisms of small-molecule binding to intrinsically disordered proteins.Targeting of the MYCN protein with small molecule c-MYC inhibitorsTargeting intrinsically disordered proteins in rational drug discovery.Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein.Pharmacokinetic modeling optimizes inhibition of the 'undruggable' EWS-FLI1 transcription factor in Ewing Sarcoma.Methods of probing the interactions between small molecules and disordered proteins.Pharmacophore identification of c-Myc inhibitor 10074-G5Current and emerging opportunities for molecular simulations in structure-based drug design.Replica state exchange metadynamics for improving the convergence of free energy estimates.
P2860
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P2860
The impact of small molecule binding on the energy landscape of the intrinsically disordered protein C-myc
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2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
The impact of small molecule b ...... cally disordered protein C-myc
@ast
The impact of small molecule b ...... cally disordered protein C-myc
@en
The impact of small molecule b ...... cally disordered protein C-myc
@nl
type
label
The impact of small molecule b ...... cally disordered protein C-myc
@ast
The impact of small molecule b ...... cally disordered protein C-myc
@en
The impact of small molecule b ...... cally disordered protein C-myc
@nl
prefLabel
The impact of small molecule b ...... cally disordered protein C-myc
@ast
The impact of small molecule b ...... cally disordered protein C-myc
@en
The impact of small molecule b ...... cally disordered protein C-myc
@nl
P2860
P1433
P1476
The impact of small molecule b ...... cally disordered protein C-myc
@en
P2093
Julien Michel
Rémi Cuchillo
P2860
P304
P356
10.1371/JOURNAL.PONE.0041070
P407
P577
2012-01-01T00:00:00Z