UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
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Histone demethylases in chromatin biology and beyondGenetic, epigenetic, and environmental contributions to neural tube closureThe Maternal Effect Genes UTX and JMJD3 Play Contrasting Roles in Mus musculus Preimplantation Embryo Development.Human UTY(KDM6C) Is a Male-specific N -Methyl Lysyl DemethylaseA primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissuesFemale bias in Rhox6 and 9 regulation by the histone demethylase KDM6AInhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts.The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two.The H3K27me3 demethylase UTX in normal development and disease.X chromosome regulation: diverse patterns in development, tissues and disease.KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.Mammalian Y chromosomes retain widely expressed dosage-sensitive regulatorsUTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.Histone lysine demethylases in mammalian embryonic development.Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells.Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.Roles of the Y chromosome genes in human cancers.Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells.Influence of Sex on Basal and Dickkopf-1 Regulated Gene Expression in the Bovine Morula.Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation.Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate RegulationHistone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiationChromosome Y genetic variants: impact in animal models and on human diseaseThe H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent mannerT Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemiaThe importance of having two X chromosomes.The epigenetic role of vitamin C in health and disease.UTX demethylase activity is required for satellite cell-mediated muscle regeneration.Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate.Epigenetic Dysfunction in Turner Syndrome Immune Cells.An essential role for UTX in resolution and activation of bivalent promoters.Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation.TALEN-mediated editing of the mouse Y chromosome.Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX.Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10.Biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins.
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P2860
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
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2012 nî lūn-bûn
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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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UTX and UTY demonstrate histon ...... in mouse embryonic development
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UTX and UTY demonstrate histon ...... in mouse embryonic development
@en
UTX and UTY demonstrate histon ...... in mouse embryonic development
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UTX and UTY demonstrate histon ...... in mouse embryonic development
@ast
UTX and UTY demonstrate histon ...... in mouse embryonic development
@en
UTX and UTY demonstrate histon ...... in mouse embryonic development
@nl
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UTX and UTY demonstrate histon ...... in mouse embryonic development
@ast
UTX and UTY demonstrate histon ...... in mouse embryonic development
@en
UTX and UTY demonstrate histon ...... in mouse embryonic development
@nl
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UTX and UTY demonstrate histon ...... in mouse embryonic development
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Karl B Shpargel
Terry Magnuson
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10.1371/JOURNAL.PGEN.1002964
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2012-09-01T00:00:00Z