Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
about
A balancing act: efflux/influx in mycobacterial drug resistanceSpecificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug PyrazinamideHigh-Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into the Catalytic Mechanism and Inhibition by Aldehydes,Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to PyrazinamideThe Leishmania nicotinamidase is essential for NAD+ production and parasite proliferationStructural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiaeMolecular dynamics simulations suggest ligand's binding to nicotinamidase/pyrazinamidaseFunctional characterization of DnaB helicase and its modulation by single-stranded DNA binding protein in Mycobacterium tuberculosisBiochemical and mutational analysis of a novel nicotinamidase from Oceanobacillus iheyensis HTE831Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic LibrariesMechanisms of Pyrazinamide Action and ResistanceSystematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism.The mycobacterial LysR-type regulator OxyS responds to oxidative stress and negatively regulates expression of the catalase-peroxidase gene.NAD+ auxotrophy is bacteriocidal for the tubercle bacilli.Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds.Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosisPhenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Zhejiang, ChinaMechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosis pyrazinamidase enzyme and pyrazinamide susceptibility.Metal-ion effects on the polarization of metal-bound water and infrared vibrational modes of the coordinated metal center of Mycobacterium tuberculosis pyrazinamidase via quantum mechanical calculations.Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase.Improved Detection by Next-Generation Sequencing of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates.Multicenter Study of the Emergence and Genetic Characteristics of Pyrazinamide-Resistant Tuberculosis in ChinaEffect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosisMicrobial metabolism of pyrazines.'Z(S)-MDR-TB' versus 'Z(R)-MDR-TB': improving treatment of MDR-TB by identifying pyrazinamide susceptibilityIn Silico Prediction of Antibiotic Resistance in Mycobacterium ulcerans Agy99 through Whole Genome Sequence Analysis.Biochemical characterization of a new nicotinamidase from an unclassified bacterium thriving in a geothermal water stream microbial mat community.Elucidation of beta-oxidation pathways in Ralstonia eutropha H16 by examination of global gene expression.A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.Insight to pyrazinamide resistance in Mycobacterium tuberculosis by molecular docking.Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis.A Key Enzyme of the NAD+ Salvage Pathway in Thermus thermophilus: Characterization of Nicotinamidase and the Impact of Its Gene Deletion at High Temperatures.Mutations found in the pncA gene of Mycobacterium tuberculosis in clinical pyrazinamide-resistant isolates from a local region of China.Density functional and molecular docking studies towards investigating the role of single-wall carbon nanotubes as nanocarrier for loading and delivery of pyrazinamide antitubercular drug onto pncA protein.Drug resistance mechanism of PncA in Mycobacterium tuberculosis.Role of pncA gene mutations W68R and W68G in pyrazinamide resistance.Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance.Pyrazinamide Is a Two-Edged Sword: Do WHO Guidelines Matter?NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs.
P2860
Q24644870-1B00FD0C-FB8B-4473-AE78-DF84A6808517Q27657995-8A65BC68-E995-4BD5-94BE-193920863611Q27664600-BDF118BA-57C5-43BA-BE7F-474C73F48532Q27666806-A318C16A-EB36-4842-ACBF-D86B9BA5A37FQ27671551-7BAC89B4-8B6A-4202-BBAF-6F1F12EA1F16Q27676645-6BD792C0-EC7E-4DC0-9F0D-F162D1E8B40CQ28480662-AD35A8FE-80ED-4CE5-A51F-1CFA7A318C4AQ28486513-A300127B-C6EF-4091-9D46-80241EE39152Q28486735-568AAD87-DD66-464A-80E1-485080A18F38Q28817696-0D458A87-5929-452E-ABC8-515A87B1AD10Q29304444-EA0B77C2-BF17-4268-A937-0DB0B62701D4Q30419570-AF700344-6834-4832-9F0A-38601DC05163Q30429278-D2BF1C84-2A6C-4346-8D5C-232D34D130EEQ31046324-3EEF1C6B-9739-4E7D-A08B-6217AE83E1E4Q34155799-3FDFB6AB-A49A-40B8-8EAF-3F27B434CBC2Q34644335-BC245E61-31A6-4E88-8C22-D320A3CDE8BBQ34757821-CF15DE70-E577-4438-BE56-120E58D07509Q35076847-46359162-8B81-41E5-89D2-8DE7800D7C8FQ35566384-7EF829CC-99D0-4FDA-A95C-BDDA97288999Q35886968-20581AA1-4CE5-4C13-B3B1-97CD6FF4C532Q36080072-CF46B7AA-D7CD-4D2E-9111-F09911AB0F22Q36297624-55FEDEDF-7C82-4408-BF5F-FCAC4E35A67CQ37203722-77D43316-D0D4-4C86-BC61-85E62DAD1D51Q37215691-BFAB995C-BD0F-49BF-83F9-571BC76EA9D9Q37863675-1D7E32D6-F3ED-44F3-9FB6-B494295EC4E6Q38514218-C2006F83-AFB1-42F1-9A63-E8E2E2C31690Q40117191-865718F4-2595-456F-823F-84D8DBB47CE0Q41153151-BA7F5787-58EC-44AB-ACAD-FE2DD9F0D582Q41826653-2E467371-D5E5-4AFA-B1E9-81718A87E092Q41986907-2B1DC1F7-397A-4A41-9B6F-A0B8E16149F4Q42252197-BEBD2768-6997-41DE-B786-C25F98AF15E8Q42583812-1CCAF2CA-48CF-4A06-954E-0C1B674AA379Q43031094-21A1312A-8002-4DF2-8740-2B69F771B0D4Q43237436-9BD7DECE-7209-40D2-B6CD-E9EFF94BEBD3Q43606860-4CA79385-9C07-45CE-8BD2-B9343185DA99Q44227288-A8535F2B-FA82-4D16-83E2-B5DCDC5B6C15Q47694013-92666D08-91DA-47B3-8919-8ADA30B2C172Q48331193-B80A3331-53AF-4DD0-9C68-6DD55F512251Q48362853-57AC2E17-55C7-439C-ACD0-BC88A2800981Q53792036-3F33908E-F2BE-4DAA-A96F-812D95F11EC1
P2860
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
description
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Februar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/02/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/02/01)
@nl
наукова стаття, опублікована в лютому 2008
@uk
مقالة علمية (نشرت في فبراير 2008)
@ar
name
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@ast
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@en
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@nl
type
label
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@ast
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@en
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@nl
prefLabel
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@ast
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@en
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@nl
P2093
P2860
P1433
P1476
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
@en
P2093
Cheng-Gang Zhang
Jiao-Yu Deng
Xian-En Zhang
Ya-Feng Zhou
Ying Zhang
Zhi-Ping Zhang
P2860
P304
P356
10.1111/J.1742-4658.2007.06241.X
P407
P577
2008-02-01T00:00:00Z