Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase - Wikidata - awgldk - TriplyDB

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

http://www.wikidata.org/entity/Q28487204

about

Next-Generation High-Throughput Functional Annotation of Microbial Genomes Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis Lipoamide Channel-Binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase)Mycobacterial genes essential for the pathogen's survival in the host ¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum Emerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome.Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis.Accurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plants Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis.Bioactive food components and cancer-specific metabonomic profiles.Metabolomic strategies for the identification of new enzyme functions and metabolic pathways Quantitative mass spectrometry reveals plasticity of metabolic networks in Mycobacterium smegmatis.On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis Activity-based profiling of a physiologic aglycone library reveals sugar acceptor promiscuity of family 1 UDP-glucosyltransferases from grape.Mycobacterium tuberculosis metabolism The glyoxylate shunt is essential for CO2-requiring oligotrophic growth of Rhodococcus erythropolis N9T-4.Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.Metabolic plasticity of central carbon metabolism protects mycobacteria.E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase.Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism Minding the gaps: metabolomics mends functional genomics.An untargeted metabolomic workflow to improve structural characterization of metabolites.Systems biology approaches to understanding mycobacterial survival mechanisms.Immunological biomarkers of tuberculosis.Separation strategies for untargeted metabolomics.Innovation: Metabolomics: the apogee of the omics trilogy.Feast or famine: the host-pathogen battle over amino acids.Allostery and compartmentalization: old but not forgotten.The use of functional genomics in conjunction with metabolomics for Mycobacterium tuberculosis research.Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review.Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery.Metabolomics of Mycobacterium tuberculosis.

P2860

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P2860

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

http://www.wikidata.org/entity/Q28487204

description

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2010

@ast

scientific journal article

@en

vedecký článok (publikovaný 2010/04/23)

@sk

vědecký článek publikovaný v roce 2010

@cs

wetenschappelijk artikel (gepubliceerd op 2010/04/23)

@nl

наукова стаття, опублікована у квітні 2010

@uk

مقالة علمية (نشرت في 23-4-2010)

@ar

name

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@ast

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@en

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@nl

type

label

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

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Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@en

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

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prefLabel

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@ast

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@en

Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

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P356

J.CHEMBIOL.2010.03.009

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Chemistry and Biology

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Activity-based metabolomic pro ...... -hydroxy-3-oxoadipate synthase

@en

P2093

Caitlyn E. Dickinson

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Carl Nathan

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Christopher D. Lima

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Hong Zhao

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Kyu Y. Rhee

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Nancy M. Arango

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Steven M. Fischer

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P2860

An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network

Structure-based activity prediction for an enzyme of unknown function

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis

Genes required for mycobacterial growth defined by high density mutagenesis

Assignment of endogenous substrates to enzymes by global metabolite profiling

Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes

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323–332

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3156455

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10.1016/J.CHEMBIOL.2010.03.009

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4

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17

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Ouathek Ouerfelli

Luiz Pedro S de Carvalho

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2010-04-23T00:00:00Z

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43340956

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