Correlating a protein structure with function of a bacterial mechanosensitive channel
about
Two families of mechanosensitive channel proteinsMechanical properties of lipid bilayers and regulation of mechanosensitive function: from biological to biomimetic channelsStructure and stability of the C-terminal helical bundle of theE. colimechanosensitive channel of large conductanceLoss-of-function mutations at the rim of the funnel of mechanosensitive channel MscLTotal chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosisCysteine scanning of MscL transmembrane domains reveals residues critical for mechanosensitive channel gating.Chemically charging the pore constriction opens the mechanosensitive channel MscL.Breaking the hydrophobicity of the MscL pore: insights into a charge-induced gating mechanismGating of the mechanosensitive channel protein MscL: the interplay of membrane and proteinThe gating mechanism of the bacterial mechanosensitive channel MscL revealed by molecular dynamics simulations: from tension sensing to channel openingGating the bacterial mechanosensitive channel MscL invivo.Streptomycin potency is dependent on MscL channel expression.Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channelOpen-state disulfide crosslinking between Mycobacterium tuberculosis mechanosensitive channel subunits.Investigating lipid composition effects on the mechanosensitive channel of large conductance (MscL) using molecular dynamics simulations.Lipid bilayer pressure profiles and mechanosensitive channel gating.Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites.Genetic models of mechanotransduction: the nematode Caenorhabditis elegans.The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gatingManipulating the permeation of charged compounds through the MscL nanovalveBacterial ion channels and their eukaryotic homologues.The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the boxMechanosensitive channel gating transitions resolved by functional changes upon pore modification.Membrane tension, lipid adaptation, conformational changes, and energetics in MscL gating.A new antibiotic with potent activity targets MscL.Disulfide trapping the mechanosensitive channel MscL into a gating-transition state.Three routes to modulate the pore size of the MscL channel/nanovalveIdentification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK.Common evolutionary origins of mechanosensitive ion channels in Archaea, Bacteria and cell-walled Eukarya.The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves.On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL.The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interfaceChimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity.Confirming the revised C-terminal domain of the MscL crystal structure.On the structure of the N-terminal domain of the MscL channel: helical bundle or membrane interfacePhosphatidylinositol is crucial for the mechanosensitivity of Mycobacterium tuberculosis MscLMechanosensitivity of ion channels based on protein-lipid interactions.Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.Ionic regulation of MscK, a mechanosensitive channel from Escherichia coli.Simulation of MscL gating in a bilayer under stress.
P2860
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P2860
Correlating a protein structure with function of a bacterial mechanosensitive channel
description
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im Oktober 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/10/06)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/10/06)
@nl
наукова стаття, опублікована в жовтні 2000
@uk
name
Correlating a protein structure with function of a bacterial mechanosensitive channel
@ast
Correlating a protein structure with function of a bacterial mechanosensitive channel
@en
Correlating a protein structure with function of a bacterial mechanosensitive channel
@nl
type
label
Correlating a protein structure with function of a bacterial mechanosensitive channel
@ast
Correlating a protein structure with function of a bacterial mechanosensitive channel
@en
Correlating a protein structure with function of a bacterial mechanosensitive channel
@nl
prefLabel
Correlating a protein structure with function of a bacterial mechanosensitive channel
@ast
Correlating a protein structure with function of a bacterial mechanosensitive channel
@en
Correlating a protein structure with function of a bacterial mechanosensitive channel
@nl
P2093
P2860
P356
P1476
Correlating a protein structure with function of a bacterial mechanosensitive channel
@en
P2093
P2860
P304
31121–31127
P356
10.1074/JBC.M002971200
P407
P577
2000-10-06T00:00:00Z