Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes
about
Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureMolecular dynamics simulation and experimental verification of the interaction between cyclin T1 and HIV-1 Tat proteinsAn Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubThe domain landscape of virus-host interactomesMechanism and factors that control HIV-1 transcription and latency activationA gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation.Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination.1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.Mass spectrometry-based proteomic approaches for discovery of HIV-host interactions.Viral-host interactions that control HIV-1 transcriptional elongationEvolutionary distance of amino acid sequence orthologs across macaque subspecies: identifying candidate genes for SIV resistance in Chinese rhesus macaquesPhosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound.The mTOR Complex Controls HIV Latency.MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding.Molecular mechanisms of HIV latency.Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescenceThe BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb.Regulation of CDK9 activity by phosphorylation and dephosphorylation.Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency.Integrative biology of T cell activation.Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription.Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals.Imaging HIV-1 Genomic DNA from Entry through Productive InfectionCyclin-dependent kinases as therapeutic targets for HIV-1 infection.HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells.The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE.Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui.Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells.Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunityComparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses.BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency.HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
P2860
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P2860
Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@ast
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@en
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@nl
type
label
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@ast
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@en
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@nl
prefLabel
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@ast
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@en
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@nl
P2093
P2860
P3181
P1433
P1476
Phosphorylation of CDK9 at Ser ...... P-TEFb in CD4(+) T lymphocytes
@en
P2093
Giridharan Gokulrangan
Jonathan Karn
Manish Datt
Mark R Chance
Maxwell Cooper
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1003338
P407
P577
2013-05-02T00:00:00Z