Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
about
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferaseThematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activityMolecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesisIntestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismExpression variants of the lipogenic AGPAT6 gene affect diverse milk composition phenotypes in Bos taurusIdentification and dissection of four major QTL affecting milk fat content in the German Holstein-Friesian populationObesity and cancer progression: is there a role of fatty acid metabolism?The cell biology of fat expansionAgpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epitheliumArylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cellsResistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 miceGlycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesisAdiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor.Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay.Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest).Genetic control of de novo lipogenesis: role in diet-induced obesityGenome-wide association of milk fatty acids in Dutch dairy cattleAdipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisGlycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerolsNuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance.Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.Thematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolism.Resistance to diet-induced obesity in mice with synthetic glyoxylate shuntGlycerophosphate/Acylglycerophosphate acyltransferases.Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingPON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosisGlycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown AdipocytesThe number of x chromosomes causes sex differences in adiposity in mice.Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.Obesity and lipodystrophy--where do the circles intersect?Approaches to lipid metabolism gene identification and characterization in the postgenomic era.SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
P2860
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P2860
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
description
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im April 2006 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2006/04/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/04/01)
@nl
наукова стаття, опублікована у квітні 2006
@uk
مقالة علمية (نشرت في أبريل 2006)
@ar
name
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@ast
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@en
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@nl
type
label
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@ast
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@en
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@nl
prefLabel
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@ast
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@en
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@nl
P2093
P2860
P1476
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
@en
P2093
Anne P. Beigneux
Laurent Vergnes
Ryan Davis
Steven M. Watkins
P2860
P304
P356
10.1194/JLR.M500553-JLR200
P577
2006-04-01T00:00:00Z