IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct
about
Regulators of Slc4 bicarbonate transporter activityMolecular mechanism of pancreatic and salivary gland fluid and HCO3 secretionAcid-base transport in pancreas-new challengesEssential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutationIRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathwayParticipation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitationIrbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in miceThe divergence, actions, roles, and relatives of sodium-coupled bicarbonate transportersHuman Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.Mechanism and synergism in epithelial fluid and electrolyte secretion.cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.Ca²⁺ signaling and regulation of fluid secretion in salivary gland acinar cells.Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm.Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters.The SLC4 family of bicarbonate (HCO₃⁻) transporters.Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis.Intracellular Cl- as a signaling ion that potently regulates Na+/HCO3- transporters.IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation.Relief of autoinhibition of the electrogenic Na-HCO(3) [corrected] cotransporter NBCe1-B: role of IRBIT vs.amino-terminal truncation.IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.Euryhaline pufferfish NBCe1 differs from nonmarine species NBCe1 physiologyMolecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.Cation-coupled bicarbonate transportersConvergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na+-HCO3- cotransporters familyThe SLC26 gene family of anion transporters and channels.The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transportAhcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association.Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.Modular structure of sodium-coupled bicarbonate transportersFunctional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct.IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.Genistein induces increase in fluid pH, Na+ and HCO3(-) concentration, SLC26A6 and SLC4A4 (NBCe1)-B expression in the uteri of ovariectomized rats.Role of CFTR in epithelial physiology.Ca(2+) channels on the move.Two Phase Modulation of [Formula: see text] Entry and Cl-/[Formula: see text] Exchanger in Submandibular Glands Cells by DexmedetomidineIRBIT: it is everywhere.The cystic fibrosis of exocrine pancreasMolecular mechanisms of renal and extrarenal manifestations caused by inactivation of the electrogenic Na(+)-HCO3 (-) cotransporter NBCe1
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P2860
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct
description
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Januar 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/01/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/01/01)
@nl
наукова стаття, опублікована в січні 2009
@uk
مقالة علمية (نشرت عام 2009)
@ar
name
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@ast
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@en
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@nl
type
label
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@ast
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@en
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@nl
prefLabel
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@ast
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@en
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@nl
P2093
P2860
P921
P3181
P356
P1476
IRBIT coordinates epithelial f ...... in the murine pancreatic duct
@en
P2093
Akihiro Mizutani
Dongki Yang
Ehud Ohana
Hideaki Ando
Katsuhiko Mikoshiba
Nikolay Shcheynikov
Shmuel Muallem
Weizhong Zeng
P2860
P304
P3181
P356
10.1172/JCI36983
P407
P577
2009-01-01T00:00:00Z