Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene
about
Nuclear structure in normal and Bloom syndrome cellsBLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairDown-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathwayA maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprintsCharacterization of the enzymatic activity of hChlR1, a novel human DNA helicaseRecql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalphaThe RecQ DNA helicases in DNA repairLoss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse developmentThe C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stabilityManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerModeling the study of DNA damage responses in miceRECQL4 in genomic instability and agingThe genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discoveryCell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicaseCancer predisposition caused by elevated mitotic recombination in Bloom miceTelomere shortening exposes functions for the mouse Werner and Bloom syndrome genesMutation of the murine Bloom's syndrome gene produces global genome destabilizationRMI1 deficiency in mice protects from diet and genetic-induced obesityMitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentThe Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineageRecQ helicases: caretakers of the genomeAdipocyte hyperplasia and RMI1 in the treatment of obesity.The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci.Mouse models of human familial cancer syndromes.Mechanisms by which Bloom protein can disrupt recombination intermediates of Okazaki fragment maturation.Generation of medaka gene knockout models by target-selected mutagenesis.A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs.DNA replication arrest leads to enhanced homologous recombination and cell death in meristems of rice OsRecQl4 mutants.Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies.Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombinationLoss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.Deficiency of Bloom syndrome helicase activity is radiomimeticThe Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Null mutations in human and mouse orthologs frequently result in different phenotypes.Regulation of BLM Nucleolar LocalizationDeletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethalityChromatin remodeling, DNA damage repair and aging.Mouse models of inherited cancer syndromesRegulation of meiotic recombination and prophase I progression in mammals.
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Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene
description
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im November 1998 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 1998/11/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/11/01)
@nl
наукова стаття, опублікована в листопаді 1998
@uk
научни чланак (објављен 1998/11/01)
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name
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
@ast
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
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Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
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type
label
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
@ast
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
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Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
@nl
prefLabel
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
@ast
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
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Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
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P2093
P2860
P3181
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P1476
Stage-specific apoptosis, deve ...... e murine Bloom's syndrome gene
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P2093
P2860
P304
P3181
P356
10.1101/GAD.12.21.3382
P577
1998-11-01T00:00:00Z