Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
about
A Tale from TGF-β Superfamily for Thymus Ontogeny and FunctionCurrent perspectives of the signaling pathways directing neural crest inductionCritical transitions in early embryonic aortic arch patterning and hemodynamicsEndoglin is required for myogenic differentiation potential of neural crest stem cellsCanonical Wnt signaling functions in second heart field to promote right ventricular growthRequirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesisEphB-ephrin-B2 interactions are required for thymus migration during organogenesis.Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects.Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformationsTrigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.Control of lung development by latent TGF-β binding proteins.Absence of cardiovascular manifestations in a haploinsufficient Tgfbr1 mouse model.Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development.TGFβ superfamily signaling in the neural crest lineage.Transforming growth factor beta signaling in adult cardiovascular diseases and repair.Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation.Cooperation between the PDGF receptors in cardiac neural crest cell migration.Partitioning the heart: mechanisms of cardiac septation and valve developmentDNA methylation abnormalities in congenital heart disease.Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defectsTissue-specific expression of Cre recombinase from the Tgfb3 locusTGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent mannerTgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.Signals controlling neural crest contributions to the heart.TGFβ signaling and congenital heart disease: Insights from mouse studies.Cardiac outflow tract anomalies.Cilia and coordination of signaling networks during heart development.The functional diversity of essential genes required for mammalian cardiac development.Thrombospondins: A Role in Cardiovascular Disease.Aortopathy in Congenital Heart Disease in Adults: Aortic Dilatation with Decreased Aortic Elasticity that Impacts Negatively on Left Ventricular Function.Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis.Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree.Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects.Landmark lecture: Perloff lecture: Tribute to Professor Joseph Kayle Perloff and lessons learned from him: aortopathy in adults with CHD.Hes1 is required for the development of pharyngeal organs and survival of neural crest-derived mesenchymal cells in pharyngeal arches.Cardiovascular development and the colonizing cardiac neural crest lineage.Mechanism of aortic root dilation and cardiovascular function in tetralogy of Fallot.Asymmetric cell-matrix and biomechanical abnormalities in elastin insufficiency induced aortopathy.
P2860
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P2860
Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
scientific journal article
@en
vedecký článok (publikovaný 2006/11/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/01)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
مقالة علمية (نشرت في نوفمبر 2006)
@ar
name
Defective ALK5 signaling in th ...... d severe outflow tract defects
@ast
Defective ALK5 signaling in th ...... d severe outflow tract defects
@en
Defective ALK5 signaling in th ...... d severe outflow tract defects
@nl
type
label
Defective ALK5 signaling in th ...... d severe outflow tract defects
@ast
Defective ALK5 signaling in th ...... d severe outflow tract defects
@en
Defective ALK5 signaling in th ...... d severe outflow tract defects
@nl
prefLabel
Defective ALK5 signaling in th ...... d severe outflow tract defects
@ast
Defective ALK5 signaling in th ...... d severe outflow tract defects
@en
Defective ALK5 signaling in th ...... d severe outflow tract defects
@nl
P2093
P2860
P921
P356
P1476
Defective ALK5 signaling in th ...... d severe outflow tract defects
@en
P2093
Andre Nagy
Henry M. Sucov
Jikui Wang
Jonas Larsson
Marek Dudas
P2860
P2888
P356
10.1186/1471-213X-6-51
P577
2006-11-01T00:00:00Z
P6179
1025002962