Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus - Wikidata - awgldk - TriplyDB

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

http://www.wikidata.org/entity/Q28506516

about

The dynamic cilium in human diseases Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1 Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis Cilia and the cell cycle?A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease Regulation of STATs by polycystin-1 and their role in polycystic kidney disease Polycystin-1 cleavage and the regulation of transcriptional pathways The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium Trafficking in and to the primary cilium.Antennas of organ morphogenesis: the roles of cilia in vertebrate kidney development Physiological mechanisms and therapeutic potential of bone mechanosensing.Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1 Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.Polycystic kidney disease.Molecular advances in autosomal dominant polycystic kidney disease.Activation of a latent nuclear localization signal in the NH2 terminus of γ-ENaC initiates feedback regulation of channel activity.The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease The C-terminal tail of the polycystin-1 protein interacts with the Na,K-ATPase alpha-subunit.The cell biology of polycystic kidney disease Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.Protein phosphatase-1α interacts with and dephosphorylates polycystin-1 Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.Kidney: polycystic kidney disease.An incredible decade for the primary cilium: a look at a once-forgotten organelle.Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model.Detecting the surface localization and cytoplasmic cleavage of membrane-bound proteins.Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis.The versatile nature of the calcium-permeable cation channel TRPP2 Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling.Polycystin-1 regulates STAT activity by a dual mechanism Cilium, centrosome and cell cycle regulation in polycystic kidney disease.Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/β-catenin pathway Altered trafficking and stability of polycystins underlie polycystic kidney disease.

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P2860

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

http://www.wikidata.org/entity/Q28506516

description

2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im November 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2004/11/01)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/11/01)

@nl

наукова стаття, опублікована в листопаді 2004

@uk

مقالة علمية (نشرت في نوفمبر 2004)

@ar

name

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@ast

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@en

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

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type

label

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@ast

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@en

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@nl

prefLabel

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@ast

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@en

Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

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P1433

Journal of Clinical Investigation

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Mechanical stimuli induce clea ...... of the polycystin-1 C terminus

@en

P2093

Anton M. Bennett

http://www.w3.org/2001/XMLSchema#string

David H. Grimm

http://www.w3.org/2001/XMLSchema#string

Herve Husson

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Michael J. Caplan

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Oxana Ibraghimov-Beskrovnaya

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Peter Igarashi

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Stefan Somlo

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Thomas Hiesberger

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Thomas Hieseberger

http://www.w3.org/2001/XMLSchema#string

Tong Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Polycystin-2 is an intracellular calcium release channel

Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

PKD1 interacts with PKD2 through a probable coiled-coil domain

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

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1433–1443

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scholarly article

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3890719

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P356

10.1172/JCI21753

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P433

10

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114

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2004-11-01T00:00:00Z

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15545994

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Polycystin 1, transient receptor poteintial channel interacting

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525739

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