Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
about
The network of cytokines, receptors and transcription factors governing the development of dendritic cell subsetsComprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemiaThe transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cellsDefective nonhomologous end joining blocks B-cell development in FLT3/ITD miceSilencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.The Cytokine Flt3-Ligand in Normal and Malignant HematopoiesisInsertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypesFlt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors.Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component.Transcriptional programming of the dendritic cell network.Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitmentDifferential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors.Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B-cell precursors.Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiationCell extrinsic alterations in splenic B cell maturation in Flt3-ligand knockout mice.Computational Modeling of a Transcriptional Switch Underlying B-Lymphocyte Lineage Commitment of Hematopoietic Multipotent Cells.Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.Long Noncoding RNA Expression during Human B-Cell DevelopmentMurine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fateThe regulation of the B-cell gene expression programme by Pax5.Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineagePermissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment.Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development.Transcriptional control of early T and B cell developmental choicesSignaling proteins and transcription factors in normal and malignant early B cell development.Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients.PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML.Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants.FLT3 in lineage specification and plasticity.Single-cell RNA sequencing reveals developmental heterogeneity among early lymphoid progenitors.Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand
P2860
Q27024226-68688BFF-382F-4835-8509-7ED8B1128889Q27853385-86801894-3A9E-417D-AEDB-83B7E1E444E6Q28237020-77604A89-8921-4E29-BADD-A03E3CE39551Q28506108-4635D505-26EC-479B-86B2-4A171F324C1DQ33381545-81CB7BAD-5DB1-4F5E-94C7-CA4D5F50E8F8Q33838356-D132BD9F-B537-43AC-9389-9F1FB3639E9EQ33871572-D6E7474F-37B5-44C5-ABB4-813BD0AA58BFQ33873934-A381B376-6B94-403E-86F6-1D14AC700EEBQ34044904-C2FBE712-1270-4CA5-8D27-AB37302E6610Q34249412-E863C817-A715-4787-99FB-BA805A781E7CQ34341293-79E48699-2C73-4445-BE53-6B7A0EDAFECAQ34567472-6180A28E-DE82-47A0-ABA4-18D2AB5632DCQ34632132-FA9F343C-7A3B-4A47-81FB-02B8C286A66FQ34686624-1E56BC7F-949A-496E-9098-8603C7E89450Q35307418-C2D371E7-66A4-4C12-8A94-0D72623088A1Q35648030-4F26617F-5E8E-4CD9-9469-2AAEE9D5B0A1Q35689414-052EBC5B-5475-4568-8B5D-7ACB906ABEECQ35779892-27AA23C3-E1E4-491D-95D3-4FC90E40E6D4Q35783785-80B16794-7F6E-4BAD-ADE9-94BC72602CD8Q36355035-9AE06BC5-313C-42BF-BB79-72480855E3C2Q36485166-47C54319-04D4-4CC4-80E0-8D07CA589525Q36999672-39BDE84A-EA56-4D79-A23C-527ACD224127Q37062082-A9C4C40C-6910-44C0-84D9-AAF6024F80FFQ37515131-89DE9BFE-8894-4350-AAEB-9A95F87D1D35Q37535958-F4B6A1FC-91AB-4E95-85BD-AB1BE4C41ECDQ37676268-C9BCBA93-68D5-46CF-A327-1577E5356549Q38182644-1A9CE405-CF79-483D-92C3-7051F2DA7E8BQ38804856-797D62A7-9504-4105-947B-7F819165B5B9Q39439183-4110D8FB-9955-4334-9E66-EA123A5846B5Q39610277-2D663B1F-C836-4DA2-BB64-01BD20E368DCQ39657462-5DECDAB3-2C96-4D37-8996-6EFBA719E74CQ40553965-84D32FE0-508E-4F0C-98B3-A8F697646114Q41760980-E58FBB65-D4D6-457D-A882-2C8726E7E41AQ42078714-DB696AFF-D38D-4F76-B6BD-0F899D2606DCQ47445787-57BC1A0D-22FF-4BEF-8699-AAE46EA02ED2Q48315207-5E81A947-E397-4F9D-828C-331877F7E376Q58575837-41568F9F-B007-4B1D-A109-1C55B00FC586
P2860
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
description
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im April 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/04/15)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/04/15)
@nl
наукова стаття, опублікована у квітні 2006
@uk
مقالة علمية (نشرت في 15-4-2006)
@ar
name
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@ast
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@en
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@nl
type
label
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@ast
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@en
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@nl
prefLabel
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@ast
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@en
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@nl
P2093
P2860
P356
P1433
P1476
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
@en
P2093
Lynn M. Corcoran
Melissa L. Holmes
Sebastian Carotta
Stephen L. Nutt
P2860
P304
P356
10.1101/GAD.1396206
P577
2006-04-15T00:00:00Z