apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes
about
Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathwaysA targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolismPathway Analysis: State of the ArtModeling anterior development in mice: diet as modulator of risk for neural tube defectsA macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosisIn vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglyceridesA novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout miceA gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B geneDual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob geneLack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertilityThe mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.Large-scale in silico mapping of complex quantitative traits in inbred mice.Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI.Human luteinized granulosa cells secrete apoB100-containing lipoproteins.Sterols in spermatogenesis and sperm maturation.Core fucosylation is required for midline patterning during zebrafish development.Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancyThe use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols.Neural tube defects: from a proteomic standpointPathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mousePosttesticular sperm maturation, infertility, and hypercholesterolemia.Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice.An apolipoprotein B100 mimotope prevents obesity in mice.Hitch-hiking between cells on lipoprotein particles.MicroRNA-122 influences the development of sperm abnormalities from human induced pluripotent stem cells by regulating TNP2 expression.The hemostasis system in murine atherosclerosis.Epididymis cholesterol homeostasis and sperm fertilizing ability.Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.The role of maternal-fetal cholesterol transport in early fetal life: current insights.Genetic landmarks for defects in mouse neural tube closure.Apolipoprotein E and apolipoprotein B genotypes and risk for spina bifida.Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies.Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.Characterization of cholesterol metabolism in Sertoli cells and spermatogenesis (Review).Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.High-throughput sperm differential proteomics suggests that epigenetic alterations contribute to failed assisted reproduction.Deviant early pregnancy maternal triglyceride levels and increased risk of congenital anomalies: a prospective community-based cohort study.
P2860
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P2860
apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes
description
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1995
@ast
im November 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/11/01)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/11/01)
@nl
наукова стаття, опублікована в листопаді 1995
@uk
مقالة علمية (نشرت في نوفمبر 1995)
@ar
name
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@ast
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@en
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@nl
type
label
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@ast
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@en
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@nl
prefLabel
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@ast
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@en
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@nl
P2093
P2860
P356
P1476
apo B gene knockout in mice re ...... ansport rates in heterozygotes
@en
P2093
D. F. Markenson
E. Voyiaziakis
J. L. Breslow
K. A. Sokol
L. S. Huang
P2860
P304
P356
10.1172/JCI118269
P407
P577
1995-11-01T00:00:00Z