Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
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Inborn errors in the metabolism of glutathioneKnockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neuronsStructure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligaseManipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicityThe in vivo gene expression signature of oxidative stressLateral gene transfer and parallel evolution in the history of glutathione biosynthesis genesRecent applications of engineered animal antioxidant deficiency models in human nutrition and chronic diseaseOxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathwayDelayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signalingGlutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levelsFlesh quality loss in response to dietary isoleucine deficiency and excess in fish: a link to impaired Nrf2-dependent antioxidant defense in muscleGlutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian FailureLack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in miceIn utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protectiveNrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Dose response relationship in anti-stress gene regulatory networksThe LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesisInitial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress responseAging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stressBehavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative StressGlutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neuronsRedox regulation of ischemic limb neovascularization - What we have learned from animal studiesLoss of UCHL1 promotes age-related degenerative changes in the enteric nervous systemGSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR.An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro.Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose.Control of angiogenesis dictated by picomolar superoxide levels.Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunitsNrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice.Mitochondrial energetics and therapeutics.Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) miceRoles of reactive oxygen species and antioxidants in ovarian toxicity.γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor.Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking InterneuronsEmerging regulatory paradigms in glutathione metabolism.Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse lineGain and loss of function for glutathione synthesis: impact on advanced atherosclerosis in apolipoprotein E-deficient mice.Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis
P2860
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P2860
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
description
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Dezember 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/12/20)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/12/20)
@nl
наукова стаття, опублікована в грудні 2000
@uk
مقالة علمية (نشرت في 20-12-2000)
@ar
name
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@ast
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@en
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@nl
type
label
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@ast
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@en
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@nl
prefLabel
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@ast
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@en
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@nl
P2093
P356
P1476
Knockout of the mouse glutamat ...... e deficiency when heterozygous
@en
P2093
D. W. Nebert
H. G. Shertzer
M. Z. Dieter
T. P. Dalton
P304
P356
10.1006/BBRC.2000.3930
P407
P577
2000-12-20T00:00:00Z