Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice
about
Ascorbate as seen through plant evolution: the rise of a successful molecule?Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null MiceSynergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein foldingInaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest.Co- and Post-Translational Protein Folding in the ERLeukotriene C4 is the major trigger of stress-induced oxidative DNA damageSEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activityLifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redoxDauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding.Profiling the Reactivity of Cyclic C-Nucleophiles towards Electrophilic Sulfur in Cysteine Sulfenic AcidRedox reactions in mammalian spermatogenesis and the potential targets of reactive oxygen species under oxidative stressERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.Diverse Redoxome Reactivity Profiles of Carbon Nucleophiles.Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.Green fluorescent protein-based monitoring of endoplasmic reticulum redox poiseReactivity, Selectivity, and Stability in Sulfenic Acid Detection: A Comparative Study of Nucleophilic and Electrophilic Probes.Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway.Destroy and exploit: catalyzed removal of hydroperoxides from the endoplasmic reticulumGlutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding.Endoplasmic Reticulum Oxidative Stress Triggers Tgf-Beta-Dependent Muscle Dysfunction by Accelerating Ascorbic Acid Turnover.The role of ascorbate in protein folding.Rational design of reversible and irreversible cysteine sulfenic acid-targeted linear C-nucleophiles.Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions.Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cellsCysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants.Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells.Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction.Endoplasmic reticulum oxidase 1α is critical for collagen secretion from and membrane type 1-matrix metalloproteinase levels in hepatic stellate cells.Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis.Oxidative stress and redox regulation of gametogenesis, fertilization, and embryonic development.A Systems Biology Study in Tomato Fruit Reveals Correlations between the Ascorbate Pool and Genes Involved in Ribosome Biogenesis, Translation, and the Heat-Shock Response.Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease
P2860
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P2860
Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice
description
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
@ast
im Oktober 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/10/12)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/10/12)
@nl
наукова стаття, опублікована в жовтні 2012
@uk
مقالة علمية (نشرت في 12-10-2012)
@ar
name
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@ast
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@en
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@nl
type
label
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@ast
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@en
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@nl
prefLabel
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@ast
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@en
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@nl
P2860
P50
P921
P1433
P1476
Endoplasmic reticulum thiol ox ...... nd noncanonical scurvy in mice
@en
P2093
Ester Zito
Junichi Fujii
P2860
P356
10.1016/J.MOLCEL.2012.08.010
P577
2012-09-13T00:00:00Z