Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation
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Matrix metalloproteinases in lung biologyRadial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signalingStructural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interactionPro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagenRegulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasisTIMP-2 is required for efficient activation of proMMP-2 in vivoMembrane type 1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropinPotential regulatory relationship between the nested gene DDC8 and its host gene tissue inhibitor of metalloproteinase-2Identification of compounds that inhibit IGF-I signaling in hyperglycemia.The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversityIdentification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.Matrix metalloproteinases in tumorigenesis: an evolving paradigm.Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficits.Hyperphagia and leptin resistance in tissue inhibitor of metalloproteinase-2 deficient mice.Complex roles of tissue inhibitors of metalloproteinases in cancer.Active matrix metalloproteinase-2 activity discriminates colonic mucosa, adenomas with and without high-grade dysplasia, and cancers.Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).Matrix metalloproteinases in renal development.Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathwaysTIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesisStromelysin-1 regulates adipogenesis during mammary gland involutionControl of matrix metalloproteinase catalytic activityTissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities.Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditionsThe tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2.Regulatory mechanism of matrix metalloprotease-2 enzymatic activity by factor Xa and thrombin.MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.Functional interactions between matrix metalloproteinases and glycosaminoglycans.Targeting matrix metalloproteinase activity and expression for the treatment of viral myocarditis.Metastasis review: from bench to bedside.p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription.Individual Timp deficiencies differentially impact pro-MMP-2 activation.Regulation of TIMP-2, MT1-MMP, and MMP-2 expression during C2C12 differentiation.Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism.Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13.Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
P2860
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P2860
Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation
description
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im August 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/08/25)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/08/25)
@nl
наукова стаття, опублікована в серпні 2000
@uk
name
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@ast
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@en
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@nl
type
label
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@ast
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@en
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@nl
prefLabel
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@ast
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@en
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@nl
P2093
P2860
P356
P1476
Inactivating mutation of the m ...... ene alters proMMP-2 activation
@en
P2093
A. E. Yermovsky
G. Longenecker
H. Birkedal-Hansen
J. A. Engler
J. J. Caterina
K. Holmbäck
N. C. Caterina
P2860
P304
26416–26422
P356
10.1074/JBC.M001271200
P407
P577
2000-08-25T00:00:00Z