Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells
about
Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity lossTranscription factor regulation of pancreatic organogenesis, differentiation and maturationCooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3Pancreatic beta cells require NeuroD to achieve and maintain functional maturityAnalysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and cultureIdentification of known and novel pancreas genes expressed downstream of Nkx2.2 during developmentNkx2.2 activates the ghrelin promoter in pancreatic islet cells.A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1.Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineageRegeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy.Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Transcriptional regulation of α-cell differentiation.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreasMelatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice.Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function.Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas.MFng is dispensable for mouse pancreas development and functionInsulin producing cells derived from embryonic stem cells: are we there yet?Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage developmentSurvival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins.The endocrine pancreas: insights into development, differentiation, and diabetes.Transcriptional control of mammalian pancreas organogenesis.Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.Analysis of the transcription factor cascade that induces endocrine and exocrine cell lineages from pancreatic progenitor cells using a polyoma-based episomal vector system.Development and regeneration in the endocrine pancreasGABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2.Pax4 and Arx Represent Crucial Regulators of the Development of the Endocrine Pancreas
P2860
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P2860
Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells
description
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
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im Dezember 2007 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2007/12/15)
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vědecký článek publikovaný v roce 2007
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wetenschappelijk artikel (gepubliceerd op 2007/12/15)
@nl
наукова стаття, опублікована в грудні 2007
@uk
مقالة علمية (نشرت في 15-12-2007)
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name
Genetic identification of a no ...... et alpha, PP and epsilon cells
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Genetic identification of a no ...... et alpha, PP and epsilon cells
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Genetic identification of a no ...... et alpha, PP and epsilon cells
@nl
type
label
Genetic identification of a no ...... et alpha, PP and epsilon cells
@ast
Genetic identification of a no ...... et alpha, PP and epsilon cells
@en
Genetic identification of a no ...... et alpha, PP and epsilon cells
@nl
prefLabel
Genetic identification of a no ...... et alpha, PP and epsilon cells
@ast
Genetic identification of a no ...... et alpha, PP and epsilon cells
@en
Genetic identification of a no ...... et alpha, PP and epsilon cells
@nl
P2093
P2860
P1476
Genetic identification of a no ...... et alpha, PP and epsilon cells
@en
P2093
Christina S. Chao
Jacqueline E. Lee
Zoe L. Loomis
P2860
P304
P356
10.1016/J.YDBIO.2007.09.057
P407
P50
P577
2007-12-15T00:00:00Z