The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis
about
Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motilityAssociation of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assayMegakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionThe phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.NF-E2 p45 is important for establishing normal function of platelets.CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitorsDistinct and overlapping functional roles of Src family kinases in mouse platelets.Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.Signaling during platelet adhesion and activationRegulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase.Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.Differential expression of CD148 on leukocyte subsets in inflammatory arthritis.Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.Tetraspanin microdomains: fine-tuning platelet function.From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension.The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function.The emergence of new therapeutic targets in pulmonary arterial hypertension: from now to the near future.Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2.STAT3 signaling in pulmonary arterial hypertension.Src family kinases: at the forefront of platelet activationIntegrin αIIbβ3 outside-in signaling.ITIM receptors: more than just inhibitors of platelet activation.Platelet proteomics applied to the search for novel antiplatelet therapeutic targets.The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis.Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma.-NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis.Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice.Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalingGrape seed extracts inhibit platelet aggregation by inhibiting protein tyrosine phosphatase.Minding the gaps--and the junctions, too.Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.Csk/CD148 and platelet SFK activation: a balancing act!
P2860
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P2860
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis
description
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
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im Mai 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2009/05/14)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/05/14)
@nl
наукова стаття, опублікована в травні 2009
@uk
مقالة علمية (نشرت في 14-5-2009)
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name
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@ast
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@en
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@nl
type
label
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@ast
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@en
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@nl
prefLabel
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@ast
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@en
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@nl
P2093
P2860
P50
P1433
P1476
The tyrosine phosphatase CD148 ...... elet activation and thrombosis
@en
P2093
Jenson Lim
Jing W Zhu
Jocelyn M Auger
Kristin N Kornerup
Stuart Ellison
Tarvinder Dhanjal
P2860
P304
P356
10.1182/BLOOD-2008-08-174318
P407
P50
P577
2009-02-25T00:00:00Z