Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear
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Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretionWNK4 regulates apical and basolateral Cl- flux in extrarenal epitheliaThe epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma modelTranscriptional control of SLC26A4 is involved in Pendred syndrome and nonsyndromic enlargement of vestibular aqueduct (DFNB4)Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model.Thyroid iodide efflux: a team effort?Collecting duct intercalated cell function and regulationControversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cellsSLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.Pendred syndrome, DFNB4, and PDS/SLC26A4 identification of eight novel mutations and possible genotype-phenotype correlationsPendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortexSLC26A2 (diastrophic dysplasia sulfate transporter) is expressed in developing and mature cartilage but also in other tissues and cell typesDifferences in the pathogenicity of the p.H723R mutation of the common deafness-associated SLC26A4 gene in humans and miceSugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangersMolecular epidemiology and functional assessment of novel allelic variants of SLC26A4 in non-syndromic hearing loss patients with enlarged vestibular aqueduct in ChinaEvolutionary insights into the unique electromotility motor of mammalian outer hair cells.Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.Do mutations of the Pendred syndrome gene, SLC26A4, confer resistance to asthma and hypertension?Integration of human and mouse genetics reveals pendrin function in hearing and deafnessTranscriptional regulation of the pendrin gene.Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear.Localization and functional studies of pendrin in the mouse inner ear provide insight about the etiology of deafness in pendred syndrome.Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China.Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.At the speed of sound: gene discovery in the auditory systemEngineered pendrin protein, an anion transporter and molecular motor.Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse modelImmunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney.Deafness and cochlear fibrocyte alterations in mice deficient for the inner ear protein otospiralin.Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression.Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin.Establishment of a knock-in mouse model with the SLC26A4 c.919-2A>G mutation and characterization of its pathologyCommon molecular etiologies are rare in nonsyndromic Tibetan Chinese patients with hearing impairment.Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis.The WNKs: atypical protein kinases with pleiotropic actions.Identification of genes concordantly expressed with Atoh1 during inner ear development.Bicarbonate transport proteins.Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertilityUsing the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death
P2860
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P2860
Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear
description
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1999
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im August 1999 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1999/08/17)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/08/17)
@nl
наукова стаття, опублікована в серпні 1999
@uk
name
Expression pattern of the mous ...... e for pendrin in the inner ear
@ast
Expression pattern of the mous ...... e for pendrin in the inner ear
@en
Expression pattern of the mous ...... e for pendrin in the inner ear
@nl
type
label
Expression pattern of the mous ...... e for pendrin in the inner ear
@ast
Expression pattern of the mous ...... e for pendrin in the inner ear
@en
Expression pattern of the mous ...... e for pendrin in the inner ear
@nl
prefLabel
Expression pattern of the mous ...... e for pendrin in the inner ear
@ast
Expression pattern of the mous ...... e for pendrin in the inner ear
@en
Expression pattern of the mous ...... e for pendrin in the inner ear
@nl
P2093
P2860
P3181
P356
P1476
Expression pattern of the mous ...... e for pendrin in the inner ear
@en
P2093
E. D. Green
L. A. Everett
P2860
P304
P3181
P356
10.1073/PNAS.96.17.9727
P407
P577
1999-08-17T00:00:00Z