The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
about
The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleusTranscriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cellsA pilot proteomic study of amyloid precursor interactors in Alzheimer's diseaseStructural basis for polyproline recognition by the FE65 WW domainHerp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stressThe gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signalingThe amyloid-beta precursor protein: integrating structure with biological functionPTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid raftsPathways towards and away from Alzheimer's diseaseThe Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifThe amyloid precursor protein: beyond amyloidInsulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleThe presenilinsDeletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's diseaseInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseThe multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesFE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.Crystal structure of the human Fe65-PTB1 domainRole of Drosophila Amyloid Precursor Protein in Memory FormationThe Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragmentsProcessing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcriptionFe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expressionCoordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivationThe Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseCytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug developmentPhenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cellsEssential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damageThe in vivo brain interactome of the amyloid precursor proteinLong-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in miceMultiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcriptionInsulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)Amyloid precursor protein interacts with notch receptorsPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionPicomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.
P2860
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P2860
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
description
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Oktober 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/10/26)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/10/26)
@nl
наукова стаття, опублікована в жовтні 2001
@uk
name
The intracellular domain of th ...... nucleus in a notch-like manner
@ast
The intracellular domain of th ...... nucleus in a notch-like manner
@en
The intracellular domain of th ...... nucleus in a notch-like manner
@nl
type
label
The intracellular domain of th ...... nucleus in a notch-like manner
@ast
The intracellular domain of th ...... nucleus in a notch-like manner
@en
The intracellular domain of th ...... nucleus in a notch-like manner
@nl
prefLabel
The intracellular domain of th ...... nucleus in a notch-like manner
@ast
The intracellular domain of th ...... nucleus in a notch-like manner
@en
The intracellular domain of th ...... nucleus in a notch-like manner
@nl
P2093
P3181
P356
P1476
The intracellular domain of th ...... nucleus in a notch-like manner
@en
P2093
D. J. Selkoe
J. B. Zheng
S. Y. Guénette
W. T. Kimberly
P304
40288–40292
P3181
P356
10.1074/JBC.C100447200
P407
P577
2001-10-26T00:00:00Z