P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
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Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal womenCrosstalk between purinergic receptors and lipid mediators in leishmaniasisPhysiological mechanisms and therapeutic potential of bone mechanosensing.Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizationsExocrine pancreatic carcinogenesis and autotaxin expressionLoss of ATRX does not confer susceptibility to osteoarthritisShockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors.Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expressionLoss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice.Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouseNon-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkersTrophic activity of human P2X7 receptor isoforms A and B in osteosarcoma.Purinergic signaling is required for fluid shear stress-induced NF-κB translocation in osteoblastsPasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.Caveolin-1 regulates P2X7 receptor signaling in osteoblastsExtracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation.Regulation of gene expression and subcellular protein distribution in MLO-Y4 osteocytic cells by lysophosphatidic acid: Relevance to dendrite outgrowthTranscriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation.Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays.Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells.Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fracturesModulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for BisphosphonatesAssociation between P2X7 Receptor Polymorphisms and Bone Status in Mice.Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout MiceP2X7 Receptor Function in Bone-Related Cancer.Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering.Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorptionAssociation of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.Expression, signaling, and function of P2X7 receptors in bone.P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineageGenetics of the P2X7 receptor and human disease.Purinergic signalling in the musculoskeletal system.Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view.The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells.
P2860
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P2860
P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
description
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Juni 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/06/02)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/06/02)
@nl
наукова стаття, опублікована в червні 2008
@uk
مقالة علمية (نشرت في 2-6-2008)
@ar
name
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@ast
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@en
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@nl
type
label
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@ast
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@en
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@nl
prefLabel
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@ast
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@en
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@nl
P2093
P2860
P921
P3181
P356
P1476
P2X7 receptors on osteoblasts ...... ng axis promoting osteogenesis
@en
P2093
Fred Possmayer
Joseph T. Rogers
Luis Pastor Solano-Flores
Nattapon Panupinthu
S. Jeffrey Dixon
Stephen M. Sims
P2860
P304
P3181
P356
10.1083/JCB.200708037
P407
P577
2008-06-02T00:00:00Z