The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
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Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actinCyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitisCoronin-1A: immune deficiency in humans and miceActin cytoskeletal defects in immunodeficiencyCoronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signalingActivation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activityThe actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.Pathogenic mechanisms in systemic lupus erythematosus.T-cell and B-cell signaling biomarkers and treatment targets in lupus.Mast cell function is not altered by Coronin-1A deficiency.Murine models of systemic lupus erythematosusT/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome.Gene expression profiles associated with aging and mortality in humans.A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cellsGRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1APre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr miceAltered cell-cell and cell-matrix interactions in the development of systemic autoimmunity.A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus miceSevere combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletionEndosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupusImmune pathology associated with altered actin cytoskeleton regulation.Unraveling the enigma: progress towards understanding the coronin family of actin regulators.TLR7 and TLR9 in SLE: when sensing self goes wrong.On guard: coronin proteins in innate and adaptive immunity.Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses.Actin cytoskeleton control of the comings and goings of T lymphocytes.The expanding spectrum of human coronin 1A deficiency.Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.Coronins and their role in immunological phenomenaNovel protein kinase C θ: coronin 1A complex in T lymphocytes.Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry.Immunodeficiency: when T cells are stuck at home.A Coronin 1-Dependent Decision Switch in Juvenile Mice Determines the Population of the Peripheral Naive T Cell Compartment.Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.The development of autoimmune features in aging mice is closely associated with alterations of the peripheral CD4⁺ T-cell compartment.
P2860
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P2860
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
@nl
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@ast
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@en
type
label
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
@nl
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@ast
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@en
prefLabel
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
@nl
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@ast
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@en
P2093
P2860
P1433
P1476
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
@en
P2093
Argyrios N Theofilopoulos
Brian R Lawson
Christine A Louis-Dit-Sully
Dwight H Kono
Gabriel Sternik
M Katarina Haraldsson
Marie-Laure Santiago-Raber
P2860
P356
10.1016/J.IMMUNI.2007.11.023
P407
P577
2008-01-01T00:00:00Z