Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
about
Subcellular distribution of Wnt pathway proteins in normal and neoplastic colonIdentification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEFEB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stabilityRole of APC and DNA mismatch repair genes in the development of colorectal cancers.Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerUnderstanding phenotypic variation in rodent models with germline Apc mutationsAnimal models of colorectal cancerAxin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilonTesting models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signalingColorectal cancer and genetic alterations in the Wnt pathwayThe β-catenin destruction complexActin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cellsGenetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoAPC-dependent suppression of colon carcinogenesis by PPARgammaSomatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activitydifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliMlh1 deficiency enhances several phenotypes of Apc(Min)/+ miceNuclear APCA knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.Genetic mechanisms in Apc-mediated mammary tumorigenesisA targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesisMouse models for colorectal cancer.Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localizationMouse models for unraveling the importance of diet in colon cancer prevention.Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus.beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous woundsInactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferationWingless-type frizzled protein receptor signaling and its putative role in human colon cancer.Complete deletion of Apc results in severe polyposis in mice.A targeted mutation of Nkd1 impairs mouse spermatogenesis.Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.The ins and outs of APC and beta-catenin nuclear transport.Identification of novel mutations by exome sequencing in African American colorectal cancer patientsDeconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signalingThe PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo.Familial adenomatous polyposis: more evidence for disease diversity and genetic heterogeneityPhosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.
P2860
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P2860
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
description
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Mai 1999 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1999/05/15)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/05/15)
@nl
наукова стаття, опублікована в травні 1999
@uk
مقالة علمية (نشرت في 15-5-1999)
@ar
name
Apc1638T: a mouse model deline ...... tumorigenesis and development
@ast
Apc1638T: a mouse model deline ...... tumorigenesis and development
@en
Apc1638T: a mouse model deline ...... tumorigenesis and development
@nl
type
label
Apc1638T: a mouse model deline ...... tumorigenesis and development
@ast
Apc1638T: a mouse model deline ...... tumorigenesis and development
@en
Apc1638T: a mouse model deline ...... tumorigenesis and development
@nl
prefLabel
Apc1638T: a mouse model deline ...... tumorigenesis and development
@ast
Apc1638T: a mouse model deline ...... tumorigenesis and development
@en
Apc1638T: a mouse model deline ...... tumorigenesis and development
@nl
P2093
P2860
P3181
P356
P1433
P1476
Apc1638T: a mouse model deline ...... tumorigenesis and development
@en
P2093
C. Breukel
C. Zurcher
J. van Dijk
K. Neufeld
M. F. Kielman
N. Hofland
P. M. Khan
R. Kucherlapati
P2860
P304
P3181
P356
10.1101/GAD.13.10.1309
P577
1999-05-15T00:00:00Z