Functional domains of axin. Importance of the C terminus as an oligomerization domain
about
Molecular basis of Wnt activation via the DIX domain protein Ccd1Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletionStructural basis of the Axin-adenomatous polyposis coli interactionDishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-cateninThe links between axin and carcinogenesisDimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinaseInteraction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction.Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functionsWnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.The structural and functional determinants of the Axin and Dishevelled DIX domainsAxin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways.The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Molecular causes of colon cancer.Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction.Modeling the effect of APC truncation on destruction complex function in colorectal cancer cellsA Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with DishevelledWnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcriptionAssembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin.Crystallization and preliminary X-ray crystallographic studies of the axin DIX domainNew insights into the regulation of Axin function in canonical Wnt signaling pathway.AXIN1 and AXIN2 variants in gastrointestinal cancers.Effects of rat Axin domains on axis formation in Xenopus embryos.Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization.Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin.Biochemical characterization of the Drosophila axin protein.An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function.Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach.The roles of intrinsic disorder in orchestrating the Wnt-pathway.
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Functional domains of axin. Importance of the C terminus as an oligomerization domain
description
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Mai 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/05/14)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/05/14)
@nl
наукова стаття, опублікована в травні 1999
@uk
name
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@ast
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@en
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@nl
type
label
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@ast
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@en
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@nl
prefLabel
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@ast
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@en
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@nl
P2860
P921
P356
P1476
Functional domains of axin. Importance of the C terminus as an oligomerization domain
@en
P2093
C. Sakanaka
L. T. Williams
P2860
P304
14090–14093
P356
10.1074/JBC.274.20.14090
P407
P577
1999-05-14T00:00:00Z