A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system
about
Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestryLRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseLRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophreniaLRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse developmentComposition of the synaptic PSD-95 complexLeucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiationNeuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neuronsSynaptic cell adhesionThe neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivoLRRTM2 functions as a neurexin ligand in promoting excitatory synapse formationOrigin and loss of nested LRRTM/α-catenin genes during vertebrate evolutionLRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour.An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizersImpaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophreniaGenome-wide association study identifies multiple susceptibility loci for pulmonary fibrosisA genome-wide association study of attempted suicide.LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex.Chick Lrrn2, a novel downstream effector of Hoxb1 and Shh, functions in the selective targeting of rhombomere 4 motor neuronsThe extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns.Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous systemConfronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasisIntercellular protein-protein interactions at synapses.Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomicsA CTNNA3 compound heterozygous deletion implicates a role for αT-catenin in susceptibility to autism spectrum disorderEndogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination trainingSynaptic organizing complexes.Slitrks as emerging candidate genes involved in neuropsychiatric disordersNeurexins, neuroligins and LRRTMs: synaptic adhesion getting fishyLRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).Mutation of Elfn1 in mice causes seizures and hyperactivity.Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice.The search for endogenous siRNAs in the mammalian brainAnalysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural developmentPathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism.Comparative gene expression analysis of the human periodontal ligament in deciduous and permanent teeth.Estrogen effects on cognition and hippocampal transcription in middle-aged mice.Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1.How are neurons wired to form functional and plastic circuits? Meeting on Axon Guidance, Synaptogenesis & Neural PlasticityIdentification of gene transcripts expressed by postsynaptic neurons during synapse formation encoding cell surface proteins with presumptive synaptogenic activity.The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks.
P2860
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P2860
A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system
description
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im April 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/04/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/04/01)
@nl
наукова стаття, опублікована у квітні 2003
@uk
مقالة علمية (نشرت في أبريل 2003)
@ar
name
A novel gene family encoding l ...... xpressed in the nervous system
@ast
A novel gene family encoding l ...... xpressed in the nervous system
@en
A novel gene family encoding l ...... xpressed in the nervous system
@nl
type
label
A novel gene family encoding l ...... xpressed in the nervous system
@ast
A novel gene family encoding l ...... xpressed in the nervous system
@en
A novel gene family encoding l ...... xpressed in the nervous system
@nl
prefLabel
A novel gene family encoding l ...... xpressed in the nervous system
@ast
A novel gene family encoding l ...... xpressed in the nervous system
@en
A novel gene family encoding l ...... xpressed in the nervous system
@nl
P2093
P921
P3181
P1433
P1476
A novel gene family encoding l ...... xpressed in the nervous system
@en
P2093
Juha Laurén
Mart Saarma
Tõnis Timmusk
P304
P3181
P356
10.1016/S0888-7543(03)00030-2
P577
2003-04-01T00:00:00Z