G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
about
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose toleranceDisruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function.The G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice.GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healingGPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampusChemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.Zinc homeostasis and signaling in health and diseases: Zinc signaling.Zinc and insulin in pancreatic beta-cells.Zinc and myocardial ischemia/reperfusion injury.Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.Fatty acid and mineral receptors as drug targets for gastrointestinal disorders.GPR39 receptors and actions of trace metals on pancreatic beta cell function and glucose homoeostasis.Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1 and modifies its function.β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced HyperglycemiaAutocrine effect of Zn²⁺ on the glucose-stimulated insulin secretion.Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon.Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4.Gastric bypass surgery may improve beta cell apoptosis with ghrelin overexpression in patients with BMI ≥ 32.5 kg/m(2.).Changes in obestatin gene and GPR39 receptor expression in peripheral tissues of rat models of obesity, type 1 and type 2 diabetes.G protein-coupled receptor modulation with pepducins: moving closer to the clinic
P2860
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P2860
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
description
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Juni 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/06/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/06/01)
@nl
наукова стаття, опублікована в червні 2009
@uk
مقالة علمية (نشرت في يونيو 2009)
@ar
name
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@ast
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@en
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@nl
type
label
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@ast
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@en
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@nl
prefLabel
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@ast
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@en
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@nl
P2093
P2860
P50
P356
P1433
P1476
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
@en
P2093
A. M. Ejernaes Sprinkel
Cathrine Orskov
Chunyu Jin
Frank Sundler
Jacob Hald
Mette Viberg Østergaard
Nils Wierup
Ole D. Madsen
Peter Thams
Pia Steen Petersen
P2860
P304
P356
10.1210/EN.2008-1250
P407
P50
P577
2009-06-01T00:00:00Z