Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit
about
NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growthRole of phosphorylation on the structural dynamics and function of types III and IV intermediate filamentsGenetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severityNeurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administrationSteady state dynamics of intermediate filament networks.Truncated desmin in PtK2 cells induces desmin-vimentin-cytokeratin coprecipitation, involution of intermediate filament networks, and nuclear fragmentation: a model for many degenerative diseases.A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament proteinCharacterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitroNeurofilaments are obligate heteropolymers in vivo.Intermediate filaments and disease: mutations that cripple cell strength.Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber.The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate.Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.Differential organization of desmin and vimentin in muscle is due to differences in their head domains.Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutationsThe roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro.The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formationElevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxA transgenic mouse model with an inducible skin blistering disease phenotype.Assembly properties of lamprey neurofilament subunits and their expression after spinal cord transection.Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments.Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments.Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis.A potential role for the COOH-terminal domain in the lateral packing of type III intermediate filamentsA synthetic peptide representing the consensus sequence motif at the carboxy-terminal end of the rod domain inhibits intermediate filament assembly and disassembles preformed filaments.Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons.Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene.Intermediate filaments formed de novo from tail-less cytokeratins in the cytoplasm and in the nucleus.
P2860
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P2860
Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit
description
1990 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1990
@ast
im November 1990 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1990/11/01)
@sk
vědecký článek publikovaný v roce 1990
@cs
wetenschappelijk artikel (gepubliceerd op 1990/11/01)
@nl
наукова стаття, опублікована в листопаді 1990
@uk
مقالة علمية (نشرت في نوفمبر 1990)
@ar
name
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@ast
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@en
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@nl
type
label
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@ast
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@en
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@nl
prefLabel
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@ast
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@en
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@nl
P2093
P2860
P1476
Assembly properties of dominan ...... e neurofilament (NF-L) subunit
@en
P2093
D. W. Cleveland
M. J. Monteiro
P. C. Wong
S. R. Gill
P2860
P304
P407
P433
P577
1990-11-01T00:00:00Z