Src kinase activity is essential for osteoclast function
about
Ablation of the Sam68 RNA binding protein protects mice from age-related bone lossCbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiationc-Src control of chloride channel support for osteoclast HCl transport and bone resorptionIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblOsteoclasts: what do they do and how do they do it?In vitro and in vivo assays for osteoclast apoptosisCrystal structure of human osteoclast stimulating factorPhysical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitroProline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast functionInositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humansDramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acidSyk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionDishevelled-2 docks and activates Src in a Wnt-dependent mannerRegulation of osteoclast differentiationBone-associated gene evolution and the origin of flight in birdsc-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton.3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts.Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain.M-CSF potently augments RANKL-induced resorption activation in mature human osteoclastsGPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone massRegulation of sealing ring formation by L-plastin and cortactin in osteoclasts.The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.Differential transformation capacity of Src family kinases during the initiation of prostate cancer.Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorptionCalpain is required for normal osteoclast function and is down-regulated by calcitoninOsteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation.Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair.Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast FunctionAcid sensing in renal epithelial cells.Emerging targeted therapies for castration-resistant prostate cancer.
P2860
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P2860
Src kinase activity is essential for osteoclast function
description
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im April 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/04/23)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/04/23)
@nl
наукова стаття, опублікована у квітні 2004
@uk
name
Src kinase activity is essential for osteoclast function
@ast
Src kinase activity is essential for osteoclast function
@en
Src kinase activity is essential for osteoclast function
@nl
type
label
Src kinase activity is essential for osteoclast function
@ast
Src kinase activity is essential for osteoclast function
@en
Src kinase activity is essential for osteoclast function
@nl
prefLabel
Src kinase activity is essential for osteoclast function
@ast
Src kinase activity is essential for osteoclast function
@en
Src kinase activity is essential for osteoclast function
@nl
P2093
P3181
P356
P1476
Src kinase activity is essential for osteoclast function
@en
P2093
Archana Sanjay
Roland Baron
Sakae Tanaka
Tsuyoshi Miyazaki
William C. Horne
P304
17660–17666
P3181
P356
10.1074/JBC.M311032200
P407
P577
2004-04-23T00:00:00Z