Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide

Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide

Item
http://www.wikidata.org/entity/Q28534943
Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' AdductsThe N-terminus of RPA large subunit and its spatial position are important for the 5'->3' resection of DNA double-strand breaks.DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair.Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.Mitoxantrone, More than Just Another Topoisomerase II Poison.CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage.FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar.Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.A flow cytometry-based method for a high-throughput analysis of drug-stabilized topoisomerase II cleavage complexes in human cells.Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context.
P2860

Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide

Item
http://www.wikidata.org/entity/Q28534943
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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Replication-dependent and tran ...... ase 2-targeting drug etoposide
@ast
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@en
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@nl
type
label
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@ast
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@en
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@nl
prefLabel
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@ast
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@en
Replication-dependent and tran ...... ase 2-targeting drug etoposide
@nl
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Replication-dependent and tran ...... ase 2-targeting drug etoposide
@en
P2093
P2860
P304
P31
P3181
P356
10.1371/JOURNAL.PONE.0079202
P407
P433
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P5875
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P932