Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity
about
Insights into Mechanisms of Chronic NeurodegenerationSynthesis of high titer infectious prions with cofactor molecules.Comparison of 2 synthetically generated recombinant prions.Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA.Nucleic acid induced unfolding of recombinant prion protein globular fragment is pH dependent.A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.A systematic investigation of production of synthetic prions from recombinant prion proteinPrion nucleation site unmasked by transient interaction with phospholipid cofactor.Proteomics applications in prion biology and structure.Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms.Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity.Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion.Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque.Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion.Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies.A quantitative characterization of interaction between prion protein with nucleic acids.
P2860
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P2860
Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity
description
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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Recombinant prion protein refo ...... but lacks in vivo infectivity
@ast
Recombinant prion protein refo ...... but lacks in vivo infectivity
@en
Recombinant prion protein refo ...... but lacks in vivo infectivity
@nl
type
label
Recombinant prion protein refo ...... but lacks in vivo infectivity
@ast
Recombinant prion protein refo ...... but lacks in vivo infectivity
@en
Recombinant prion protein refo ...... but lacks in vivo infectivity
@nl
prefLabel
Recombinant prion protein refo ...... but lacks in vivo infectivity
@ast
Recombinant prion protein refo ...... but lacks in vivo infectivity
@en
Recombinant prion protein refo ...... but lacks in vivo infectivity
@nl
P2093
P2860
P1433
P1476
Recombinant prion protein refo ...... but lacks in vivo infectivity
@en
P2093
Andrew G Timmes
Elizabeth R Fischer
Roger A Moore
Suzette A Priola
P2860
P304
P356
10.1371/JOURNAL.PONE.0071081
P407
P577
2013-01-01T00:00:00Z