Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice
about
A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA InhibitorsThe Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and TherapyInhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 miceIncreased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain.Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.The emerging link between O-GlcNAc and Alzheimer disease.Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma.Tau protein modifications and interactions: their role in function and dysfunction.Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus.Mutant Huntingtin Disrupts the Nuclear Pore Complex.Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease.O-GlcNAcylation and neurodegeneration.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.The emerging link between O-GlcNAcylation and neurological disorders.O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.Recognition of diazirine-modified O-GlcNAc by human O-GlcNAcase.Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.Production of O-GlcNAc Modified Recombinant Tau in E. coli and Detection of Ser400 O-GlcNAc Tau In Vivo.Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.O-GlcNAc cycling in the developing, adult and geriatric brain.Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcaseCross-Dysregulation of -GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic DiseasesDirect Crosstalk Between -GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy
P2860
Q27702580-B8057E07-F4E0-49DF-BF91-CF84C6566ADDQ28119005-A89DA9F1-B104-4665-9E63-4E89045DA347Q33706940-9E219015-F9EB-40EF-A355-6AAB87FE2B54Q34073596-8045F04E-751F-4FCF-8844-0E819C210E9EQ34515333-29ADA254-79B4-46E2-81A5-8450F164F6C1Q34683108-679248B1-3428-4426-8E7C-FD31139EC1FCQ37130046-7DC00744-0F42-4CFC-832C-0538C4EFD8B4Q37684106-8C240592-591F-453B-8B4A-6CFBFF44FAA6Q38650852-182A0ADF-F3CF-4F24-914F-A84B1B9D4B8EQ38734025-0F8DD57D-0ED4-4A3D-8CAD-730EBD545C39Q38808280-A908564C-F6DD-4E73-9285-8C4FD9B5061EQ38920683-921ED79D-7441-4054-B431-9C87CCF1DC48Q38983187-F082665F-FA02-437C-89F0-51B467FD3C7DQ39324009-4C8BD548-4061-4D47-B754-89C92C36F383Q41064100-0E1A27D0-4B36-4DEA-96B6-96B4363EAAACQ42273521-57FECA88-5553-466D-B423-F4D7CFAAB4C2Q46533399-C131B493-94F7-41C8-BDD0-F52DB050E625Q47852182-19AFEDDF-DC86-4D7D-9224-51ED976FE159Q47880863-48B9C391-914B-44F6-A33A-875D2DB5A553Q55416370-28D6B887-3F88-48F6-A12C-0ECABAF641A2Q57810292-A228EB35-6E90-4B88-BBDD-E0CBA3FD01E2Q57816633-8031AF35-8AF2-43D3-B397-5B4530685FE1Q58553621-02984138-5B7D-4A80-94C4-BB4A74B7E059
P2860
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@ast
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@en
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@nl
type
label
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@ast
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@en
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@nl
prefLabel
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@ast
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@en
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@nl
P2093
P2860
P50
P1433
P1476
Increasing brain protein O-Glc ...... nd mortality of Tau.P301L mice
@en
P2093
Clara Theunis
Dieder Moechars
Gerard Hilaire
Harrie Gijsen
Herman Devijver
Hervé Maurin
Justin V Louis
Peter Borghgraef
P2860
P304
P356
10.1371/JOURNAL.PONE.0084442
P407
P577
2013-01-01T00:00:00Z