Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro
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Early implementation of QbD in biopharmaceutical development: a practical exampleDo not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic ProteinsIn Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein FormulationsSilicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice.Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors.Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG.Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based BiotherapeuticsA comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors.Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity.Editor's Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response.Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg?Physical Characterization and Innate Immunogenicity of Aggregated Intravenous Immunoglobulin (IGIV) in an In Vitro Cell-Based Model.Why the Immune System Should Be Concerned by Nanomaterials?Effect of growth hormone and IgG aggregates on dendritic cells activation and T-cells polarization.Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting.The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling.Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics.Microparticles and Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product.Modulating the immune system through nanotechnology.Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a.Flow microscopy imaging is sensitive to characteristics of subvisible particles in peginesatide formulations associated with severe adverse reactions.Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab.Biosimilarity under stress: A forced degradation study of Remicade® and Remsima™.
P2860
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P2860
Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Aggregation of human recombina ...... tive T-cell responses in vitro
@ast
Aggregation of human recombina ...... tive T-cell responses in vitro
@en
Aggregation of human recombina ...... tive T-cell responses in vitro
@nl
type
label
Aggregation of human recombina ...... tive T-cell responses in vitro
@ast
Aggregation of human recombina ...... tive T-cell responses in vitro
@en
Aggregation of human recombina ...... tive T-cell responses in vitro
@nl
prefLabel
Aggregation of human recombina ...... tive T-cell responses in vitro
@ast
Aggregation of human recombina ...... tive T-cell responses in vitro
@en
Aggregation of human recombina ...... tive T-cell responses in vitro
@nl
P2093
P2860
P3181
P1433
P1476
Aggregation of human recombina ...... tive T-cell responses in vitro
@en
P2093
Aida Baban
Andrea Kiessling
Anette C Karle
Babette Wolf
Jennifer Krieg
Laetitia Sordé
Marie-Claude Djidja
Sascha Gottlieb
Sebastian Spindeldreher
Stephan Koepke
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0086322
P407
P577
2014-01-01T00:00:00Z