Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates
about
Autophagy signal transduction by ATG proteins: from hierarchies to networksTherapeutic targeting of autophagy in neurodegenerative and infectious diseasesAccumulation of ubiquitin and sequestosome-1 implicate protein damage in diacetyl-induced cytotoxicityp62/SQSTM1 functions as a signaling hub and an autophagy adaptorp62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradationRetinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury.A strategy to combine pathway-targeted low toxicity drugs in ovarian cancerTRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox HomeostasisStructure and function of the ULK1 complex in autophagyCytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress.The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway.Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells.Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism.The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitinationp62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.Canonical and noncanonical functions of ULK/Atg1.Mechanisms of Autophagy Initiation.Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease.Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.Autophagy and Inflammatory Response in the Tumor Microenvironment.Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasisSqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin.The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane.Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease.Regulation of selective autophagy: the p62/SQSTM1 paradigm.The mammalian ULK1 complex and autophagy initiation.Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine.Non-canonical activation of NRF2: New insights and its relevance to disease.SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity.A Molecular Perspective of Mammalian Autophagosome Biogenesis.Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.mTOR Pathways in Cancer and Autophagy.
P2860
Q26782670-17EF4ECD-FB61-4CBD-8DAE-4CB7FEF83C01Q27021382-3557DFDF-D336-4566-A353-0AEFA7A99577Q27968923-C48C1B41-30DF-4D26-AC35-7761B41875FEQ28081418-E9A48520-A576-4981-A194-45A151C1F326Q33634619-66E81160-493D-461E-8ADE-CCFE197710B7Q36290393-A87C535F-318A-4951-814E-83FC1963CD05Q36544506-197A0864-14E3-4DB7-98AB-702FA93500E8Q36654167-CA145228-DBA3-41CB-9ACC-0B8E83FD75C4Q36788728-87696D80-F654-48C8-BE08-402045017226Q36810811-8B40A99B-FDCC-4BEB-B55A-788ECCF2C363Q37194679-559397C0-B9D9-4567-B23E-AA98A7706B62Q37263633-71D992C2-12CA-4680-BD47-78B4718BBAE8Q37491265-394DB3B5-30DD-4503-8CDC-24A509C46636Q37725403-0AB94BC0-9811-410B-A06F-06BFBB793B04Q38706163-8C8C4454-E2B2-4439-823C-100657FE6A63Q38710573-FB6C9A79-AA48-4531-B68F-ED0EA6AF9D33Q38839499-85DAC745-0BD8-4F70-BC84-AB3052D8EEFEQ38852414-3E891FAE-D3AB-4FEC-9588-E413F4C4B8D5Q38893853-2F082A6A-ABD9-4CE2-80C1-F887ABB978B5Q39178289-16678C28-1407-4B4F-9C27-7F5746A1F9C8Q39182119-B5488827-385E-48E1-845E-4AD9BAF8CDB6Q39274188-DEC8AFB2-CA03-45FA-9293-E310CFEEB74DQ39366638-2C5FF9CB-5750-4F0A-BC80-851A10266067Q41660244-2E0065DE-CBCB-438E-9BB6-B5E2478478F2Q41945707-F46DBF68-E913-4F72-B0C6-964F6A608649Q42150510-3A4F1AFA-023E-4D1F-869B-64A13776BEA1Q42173389-FD4BF70C-9C46-4796-917E-139CF87757B5Q42361268-CDC49BE2-B3BC-40CD-874B-35EBD927AB96Q43020553-1ECDDD7C-9EE2-4930-A05B-CA85C35852C8Q47097307-D14C7BDF-2AEB-4FEE-AA7D-92EE000D3B4CQ47108927-7F0109B4-F1D7-4F0B-8D2A-9DC38684E827Q47288108-B8523F1C-9739-479E-BF65-ADF038174527Q47301166-F46E75B8-5018-433C-8070-C934F4F291BAQ47301180-58B6E088-BD29-425F-91ED-501FF6BD6D4BQ47745733-A9AF41DA-52C1-4A9D-8CA9-5D874110B879Q47870645-518EF7C5-FA6D-4C91-8A76-931EC55FF7EAQ47973753-B43669C2-7AC6-4FD5-ABB0-C45487F2CCBCQ48163587-7C4C375D-056C-4608-BF29-F43AE17A6F2FQ48613873-93D91106-7538-447C-91C2-B9C81F20A261Q49259139-87626EC3-3F62-4D72-B450-DEE3C49C0B9D
P2860
Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates
description
2015 nî lūn-bûn
@nan
2015 թուականին հրատարակուած գիտական յօդուած
@hyw
2015 թվականին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Proteotoxic stress induces pho ...... learance of protein aggregates
@ast
Proteotoxic stress induces pho ...... learance of protein aggregates
@en
Proteotoxic stress induces pho ...... learance of protein aggregates
@nl
type
label
Proteotoxic stress induces pho ...... learance of protein aggregates
@ast
Proteotoxic stress induces pho ...... learance of protein aggregates
@en
Proteotoxic stress induces pho ...... learance of protein aggregates
@nl
prefLabel
Proteotoxic stress induces pho ...... learance of protein aggregates
@ast
Proteotoxic stress induces pho ...... learance of protein aggregates
@en
Proteotoxic stress induces pho ...... learance of protein aggregates
@nl
P2093
P2860
P50
P3181
P1433
P1476
Proteotoxic stress induces pho ...... learance of protein aggregates
@en
P2093
Junghyun Lim
M Lenard Lachenmayer
Wenchao Liu
Young J Oh
Zhenyu Yue
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1004987
P407
P577
2015-01-01T00:00:00Z