Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation - Wikidata - awgldk - TriplyDB

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

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Targeting the latent reservoir to achieve functional HIV cure Might dolutegravir be part of a functional cure for HIV?Targeting the Brain Reservoirs: Toward an HIV Cure Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4 HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection Chemical probes targeting epigenetic proteins: Applications beyond oncology.Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation Euphorbia Kansui Reactivates Latent HIV.The effect of Ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells.Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β.The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb.The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication.HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20/TNFAIP3 in NF-κB Signaling HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1.In vitro effects of the small-molecule protein kinase C agonists on HIV latency reactivation.Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo.HIV-1 Eradication: Early Trials (and Tribulations).Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.Connecting HIV-1 integration and transcription: a step toward new treatments.Ingenane Diterpenoids.Current views on HIV-1 latency, persistence, and cure.Cyclin-dependent kinases as therapeutic targets for HIV-1 infection.Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma.Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui.HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies.Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition.HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site.In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.Natural products and HIV/AIDS.The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency.A new quinoline BRD4 inhibitor targets a distinct latent HIV-1 reservoir for re-activation from other 'shock' drugs.Compounds producing an effective combinatorial regimen for disruption of HIV-1 latency.HIV latency is reversed by ACSS2-driven histone crotonylation.Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents.Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency.

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Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

http://www.wikidata.org/entity/Q28546901

description

2015 nî lūn-bûn

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2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2015 թվականի հուլիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Synergistic Reactivation of La ...... JQ1 Induced p-TEFb Activation

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Synergistic Reactivation of La ...... JQ1 Induced p-TEFb Activation

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Anne Fenton

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Daniel P Wong

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Erica A Mendes

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Gregory P Melcher

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Philipp Kaiser

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P2860

Targeting NF-κB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency

Early mucosal sensing of SIV infection by paneth cells induces IL-1β production and initiates gut epithelial disruption

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

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