17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

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HSD17B2 oxidises estradiol (E2) to estrone (E1)Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery

P2860

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P2860

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

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2015 nî lūn-bûn

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2015 թուականին հրատարակուած գիտական յօդուած

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2015 թվականին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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P1476

17β-Hydroxysteroid Dehydrogena ...... Enzyme and Its Murine Ortholog

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P2093

Angelo Carotti

http://www.w3.org/2001/XMLSchema#string

Chris Van Koppen

http://www.w3.org/2001/XMLSchema#string

Enrico Perspicace

http://www.w3.org/2001/XMLSchema#string

Giuseppe Allegretta

http://www.w3.org/2001/XMLSchema#string

Martin Frotscher

http://www.w3.org/2001/XMLSchema#string

Rolf W Hartmann

http://www.w3.org/2001/XMLSchema#string

Sandrine Marchais-Oberwinkler

http://www.w3.org/2001/XMLSchema#string

P2860

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

17Beta-hydroxysteroid dehydrogenases in human bone cells

Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.

Development of a biological screening system for the evaluation of highly active and selective 17beta-HSD1-inhibitors as potential therapeutic agents.

Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors.

Osteoporosis prevention, diagnosis, and therapy.

Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta.

Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase activity in human placental microsomes.

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e0134754

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scholarly article

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10.1371/JOURNAL.PONE.0134754

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English

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Emanuele M Gargano

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2015-01-01T00:00:00Z

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280592019

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26230928

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4521925

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17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

about

P2860

P2860

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P932