Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model
about
Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2aHeantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing.A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane.The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels.Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons.
P2860
Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model
description
2015 nî lūn-bûn
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2015 թուականին հրատարակուած գիտական յօդուած
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2015 թվականին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
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name
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@ast
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@en
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@nl
type
label
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@ast
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@en
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@nl
prefLabel
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@ast
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@en
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@nl
P2093
P2860
P1433
P1476
Z944, a Novel Selective T-Type ...... in the Amygdala Kindling Model
@en
P2093
Amy Jeffreys
Ashleigh Hicks
Pablo Miguel Casillas-Espinosa
Terrance P Snutch
P2860
P304
P356
10.1371/JOURNAL.PONE.0130012
P407
P577
2015-01-01T00:00:00Z