Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
about
Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesMutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4HRho family GTPases: key players in neuronal development, neuronal survival, and neurodegenerationLoss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal traffickingP-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor traffickingRegulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathwayNetwork inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stressEstablishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death.Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis.The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.Transgenic animal models of neurodegeneration based on human genetic studies.A comparative study of Lrrk2 function in primary neuronal cultures.Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action.Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicitySignal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.Rho-linked genes and neurological disorders.Alsin and the molecular pathways of amyotrophic lateral sclerosisALS2/alsin knockout mice and motor neuron diseases.Endocytic membrane trafficking and neurodegenerative disease.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.Rac1 and Cdc42 Play Important Roles in Arsenic Neurotoxicity in Primary Cultured Rat Cerebellar Astrocytes.Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis
P2860
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P2860
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
description
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Juli 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/07/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/07/01)
@nl
наукова стаття, опублікована в липні 2006
@uk
مقالة علمية (نشرت في يوليو 2006)
@ar
name
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@ast
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@en
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@nl
type
label
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@ast
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@en
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@nl
prefLabel
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@ast
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@en
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@nl
P2093
P2860
P356
P1433
P1476
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
@en
P2093
Christophe Beclin
Delphine Bohl
Emmanuelle Buhler
Georg Haase
Michael K E Schäfer
Stephane Blanchard
P2860
P304
P356
10.1002/ANA.20886
P577
2006-07-01T00:00:00Z