7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats
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7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disordersNovel small molecule activators of the Trk family of receptor tyrosine kinasesPolyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefitsFlavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.Not all stressors are equal: behavioral and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilizationAmygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.Animal models of post-traumatic stress disorder: face validity.Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in AmygdalaPharmacological enhancement of memory or cognition in normal subjectsBehavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence?Flavones from Erythrina falcata are modulators of fear memory7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats.Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's diseaseSmall-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice.7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.Fear extinction and BDNF: translating animal models of PTSD to the clinic.Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning.Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespanProbing the ability of presynaptic tyrosine kinase receptors to regulate striatal dopamine dynamics.Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway.Synaptic regulation of affective behaviors; role of BDNFNeurotrophic natural products: chemistry and biology.Aging impairs dendrite morphogenesis of newborn neurons and is rescued by 7, 8-dihydroxyflavoneInvestigational drugs under development for the treatment of PTSD.Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress.Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity.TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.The Small-Molecule TrkB Agonist 7, 8-Dihydroxyflavone Decreases Hippocampal Newborn Neuron Death After Traumatic Brain Injury.Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice.The Role of 7,8-Dihydroxyflavone in Preventing Dendrite Degeneration in Cortex After Moderate Traumatic Brain Injury.Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress DisorderPost-Injury Treatment of 7,8-Dihydroxyflavone Promotes Neurogenesis in the Hippocampus of the Adult Mouse.Tropomyosin Receptor Kinase B Agonist, 7,8-Dihydroxyflavone, Improves Mitochondrial Respiration in Placentas From Obese Women.Sex-dependent impact of early-life stress and adult immobilization in the attribution of incentive salience in rats.
P2860
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P2860
7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats
description
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
@ast
im März 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/03/01)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/03/01)
@nl
наукова стаття, опублікована в березні 2012
@uk
مقالة علمية (نشرت في مارس 2012)
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name
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@ast
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@en
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@nl
type
label
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@ast
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@en
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@nl
prefLabel
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@ast
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@en
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@nl
P2860
P50
P3181
P356
P1433
P1476
7,8-dihydroxyflavone, a TrkB r ...... immobilization stress in rats
@en
P2093
Núria Daviu
Raül Andero
P2860
P304
P3181
P356
10.1002/HIPO.20906
P577
2012-03-01T00:00:00Z