Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains
about
Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypesMechanistic and regulatory aspects of intestinal iron absorptionCharting the travels of copper in eukaryotes from yeast to mammalsMolecular mediators governing iron-copper interactionsMammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localizationTranscriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cellsSilencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1)Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cellsGene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunumTranscription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxiaAlternative splicing of the Menkes copper Atpase (Atp7a) transcript in the rat intestinal epitheliumSilencing of the Menkes copper-transporting ATPase (Atp7a) gene increases cyclin D1 protein expression and impairs proliferation of rat intestinal epithelial (IEC-6) cells.Promoter analysis of intestinal genes induced during iron-deprivation reveals enrichment of conserved SP1-like binding sitesInduction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators.Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ).Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake.Exploration of the copper-related compensatory response in the Belgrade rat model of genetic iron deficiencyDiscovery of a cytosolic/soluble ferroxidase in rodent enterocytes.High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats.Immunoreactive hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes.Multiple Menkes copper ATPase (Atp7a) transcript and protein variants are induced by iron deficiency in rat duodenal enterocytesMetabolic crossroads of iron and copper.Intestinal expression of metal transporters in Wilson's disease.Divalent metal transporter 1 (Dmt1) mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells.Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells.Localization of the Wilson disease protein in murine intestine.Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity.The Function of ATPase Copper Transporter ATP7B in Intestine.Consumption of a High-Iron Diet Disrupts Homeostatic Regulation of Intestinal Copper Absorption in Adolescent Mice.Counteract of bone marrow of blotchy mice against the increases of plasma copper levels induced by high-fat diets in LDLR-/- mice.Ankaferd Influences mRNA Expression of Iron-Regulated Genes During Iron-Deficiency Anemia.Role of the Menkes ATPase in the Absorption of Both Copper and Iron
P2860
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P2860
Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@ast
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@en
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@nl
type
label
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@ast
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@en
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@nl
prefLabel
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@ast
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@en
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@nl
P2093
P2860
P3181
P356
P1476
Menkes Copper ATPase (Atp7a) i ...... d basolateral membrane domains
@en
P2093
Fayez K Ghishan
James F Collins
Jennifer J Ravia
Renu M Stephen
P2860
P304
36221-36227
P3181
P356
10.1074/JBC.M506727200
P407
P577
2005-08-04T00:00:00Z