Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions
about
Analyzing effects of naturally occurring missense mutationsStructure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDEA capillary electrophoresis method for evaluation of Abeta proteolysis in vitroMolecular basis for the thiol sensitivity of insulin-degrading enzymeIdentification of the allosteric regulatory site of insulysinMolecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †Anion Activation Site of Insulin-degrading EnzymeYeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.Cloning, expression and characterization of insulin-degrading enzyme from tomato (Solanum lycopersicum).A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory propertiesMixed dimers of insulin-degrading enzyme reveal a cis activation mechanismDual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulationStructural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.Predicting potentially functional SNPs in drug-response genes.Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
P2860
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P2860
Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions
description
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 2005
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im Mai 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/05/06)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/05/06)
@nl
наукова стаття, опублікована в травні 2005
@uk
name
Mutation of active site residu ...... alters allosteric interactions
@ast
Mutation of active site residu ...... alters allosteric interactions
@en
Mutation of active site residu ...... alters allosteric interactions
@nl
type
label
Mutation of active site residu ...... alters allosteric interactions
@ast
Mutation of active site residu ...... alters allosteric interactions
@en
Mutation of active site residu ...... alters allosteric interactions
@nl
prefLabel
Mutation of active site residu ...... alters allosteric interactions
@ast
Mutation of active site residu ...... alters allosteric interactions
@en
Mutation of active site residu ...... alters allosteric interactions
@nl
P2093
P2860
P356
P1476
Mutation of active site residu ...... alters allosteric interactions
@en
P2093
Abigail Daily
Eun Suk Song
Louis B. Hersh
Luiz Juliano
Maria Aparecida Juliano
Michael G. Fried
P2860
P304
17701–17706
P356
10.1074/JBC.M501896200
P407
P577
2005-05-06T00:00:00Z