Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
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Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and PathologyCrystal structure and catalysis of the selenoprotein thioredoxin reductase 1TrxR1 as a potent regulator of the Nrf2-Keap1 response systemGold compounds as therapeutic agents for human diseasesThe effects of chromium(VI) on the thioredoxin system: implications for redox regulationThioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug targetCytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac developmentProteomic profiling of acrolein adducts in human lung epithelial cellsIndolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leadsMetal-catalyzed uncaging of DNA-binding agents in living cells†Electronic supplementary information (ESI) available: Synthesis and characterization of the studied molecules and required precursors. NMR, UV, and fluorescence spectra, titrations, contThe role of thioredoxin reductases in brain development.Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cellsPenultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver.JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling.The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities.Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein SGenes transactivated by hepatitis C virus core protein, a microarray assaySusceptibility of the antioxidant selenoenyzmes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenesRedox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling.Different Forms of Selenoprotein M Differentially Affect Aβ Aggregation and ROS GenerationAcrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidaseROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.Targeting selenium metabolism and selenoproteins: novel avenues for drug discoveryAnticancer activity of metal complexes: involvement of redox processes.Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells.Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase.Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.Metal-catalyzed uncaging of DNA-binding agents in living cells.Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells.Nanostructures Control the Hepatocellular Responses to a Cytotoxic Agent "Cisplatin".Development of chitosan-tripolyphosphate non-woven fibrous scaffolds for tissue engineering application.Wobble decoding by the Escherichia coli selenocysteine insertion machinery.Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
P2860
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P2860
Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
description
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im Mai 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/05/02)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/05/02)
@nl
наукова стаття, опублікована в травні 2003
@uk
name
Rapid induction of cell death ...... zyme containing selenocysteine
@ast
Rapid induction of cell death ...... zyme containing selenocysteine
@en
Rapid induction of cell death ...... zyme containing selenocysteine
@nl
type
label
Rapid induction of cell death ...... zyme containing selenocysteine
@ast
Rapid induction of cell death ...... zyme containing selenocysteine
@en
Rapid induction of cell death ...... zyme containing selenocysteine
@nl
prefLabel
Rapid induction of cell death ...... zyme containing selenocysteine
@ast
Rapid induction of cell death ...... zyme containing selenocysteine
@en
Rapid induction of cell death ...... zyme containing selenocysteine
@nl
P2860
P3181
P356
P1476
Rapid induction of cell death ...... zyme containing selenocysteine
@en
P2093
Karin Anestål
P2860
P304
15966-15972
P3181
P356
10.1074/JBC.M210733200
P407
P50
P577
2003-02-06T00:00:00Z