Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts
about
Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a.Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)Modulation of cardiac contractility by the phospholamban/SERCA2a regulatomeChronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusionCardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in miceGene knockout studies of Ca2+-transporting ATPasesPrenatal hypoxia induces increased cardiac contractility on a background of decreased capillary densityAltered intracellular Ca2+ handling in heart failure.Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation.SERCA pump isoforms: their role in calcium transport and disease.Perivascular fluid cuffs decrease lung compliance by increasing tissue resistance.Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (review).Discovering altered genomic expression patterns in heart: transcriptome determination by serial analysis of gene expression.Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.Comparative analysis of parvalbumin and SERCA2a cardiac myocyte gene transfer in a large animal model of diastolic dysfunction.Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling.Cardiac hypertrophy and failure: lessons learned from genetically engineered mice.Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a.Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.Analysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays.Resistance training regulates cardiac function through modulation of miRNA-214.SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart FailureDifferential regulation of myofilament protein isoforms underlying the contractility changes in skeletal muscle unloading.Learning about cardiac calcium signaling from genetic engineering.Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes.The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a.Calcium cycling proteins and heart failure: mechanisms and therapeuticsEffects of Growth Hormone on Cardiac Remodeling During Resistance Training in RatsGene transfer for congestive heart failure: update 2013.Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.Molecular basis of diastolic dysfunction.The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate.The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases.Ryanodine receptor-mediated arrhythmias and sudden cardiac death.Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.Ion channels, transporters, and pumps as targets for heart failure therapySarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes.Cardiac gene therapy with SERCA2a: from bench to bedside
P2860
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P2860
Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts
description
2016 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2016
@ast
im Dezember 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2016/12/14)
@sk
vědecký článek publikovaný v roce 2016
@cs
wetenschappelijk artikel (gepubliceerd op 2016/12/14)
@nl
наукова стаття, опублікована в грудні 2016
@uk
مقالة علمية (نشرت في 14-12-2016)
@ar
name
Targeted overexpression of the ...... ity in transgenic mouse hearts
@ast
Targeted overexpression of the ...... ity in transgenic mouse hearts
@en
Targeted overexpression of the ...... ity in transgenic mouse hearts
@nl
type
label
Targeted overexpression of the ...... ity in transgenic mouse hearts
@ast
Targeted overexpression of the ...... ity in transgenic mouse hearts
@en
Targeted overexpression of the ...... ity in transgenic mouse hearts
@nl
prefLabel
Targeted overexpression of the ...... ity in transgenic mouse hearts
@ast
Targeted overexpression of the ...... ity in transgenic mouse hearts
@en
Targeted overexpression of the ...... ity in transgenic mouse hearts
@nl
P2093
P3181
P1433
P1476
Targeted overexpression of the ...... ity in transgenic mouse hearts
@en
P2093
A Bhagwhat
E Loukianov
K Hashimoto
P304
P3181
P356
10.1161/01.RES.83.12.1205
P577
1998-12-01T00:00:00Z